US EditionRe-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines
3 Articles
3 Articles
Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines
Despite the widespread use of mRNA vaccines against COVID-19, little is known about the metabolism of therapeutic RNAs. Here we use nanopore sequencing1–3 to analyse individual therapeutic mRNA molecules, focusing on their poly(A) tails. We show that the Moderna mRNA-1273 vaccine4 has a poly(A) tail of around 100 nucleotides, followed by an mΨCmΨAG sequence. In cell lines, mRNA-1273 undergoes rapid degradation initiated by mΨCmΨAG removal, follo…
Scientists from the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) have discovered a mechanism responsible for the greater effectiveness of mRNA vaccines and therapies. As we read in the publication, which appeared in the prestigious journal "Nature", the results of this research will facilitate the creation of modern drugs against cancer and infectious diseases based on mRNA.
Moderna authorised to upscale development of mRNA vaccines in UK - Pharmafile
Global researcher of mRNA medicine, Moderna, has been granted authorisation by the Medicines and Healthcare products Regulatory Agency (MHRA) to manufacture commercial mRNA vaccines at its facility in Harwell, Oxfordshire, UK. This is a milestone in Moderna’s mission to develop a reliable supply of mRNA vaccines for pandemic-preparedness. The MHRA granted Manufacturer’s/Importer’s Authorisation (MIA) to […] The post Moderna authorised to upscale…
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