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Top pharmafile.com News

Sanofi buys US biopharma group Blueprint in $9.1 bln deal
France Economy · France

Sanofi buys US biopharma group Blueprint in $9.1 bln deal

76% Center coverage: 21 sources
See the Story
Tuning Charge Density of Chimeric Antigen Receptor Optimizes Tonic Signaling and CAR-T Cell Fitness
Gene Editing · United States

Tuning Charge Density of Chimeric Antigen Receptor Optimizes Tonic Signaling and CAR-T Cell Fitness

Coverage: 2 sources
Tonic signaling of chimeric antigen receptor (CAR), i.e., the spontaneous CAR activation in the absence of tumor antigen stimulation, is considered to be a pivotal event controlling CAR-T efficacy. However, the molecular mechanism underlying the spontaneous CAR signals remains elusive. Here, we unveil that positively charged patches (PCPs) on the surface of the CAR antigen-binding domain mediate CAR clustering and result in CAR tonic signaling. …See the Story
NIPRO introduces LiniXia water treatment system for dialysis clinics - Pharmafile
Vienna, Austria · Vienna

NIPRO introduces LiniXia water treatment system for dialysis clinics - Pharmafile

Japan-based biopharma, NIPRO, has launched LiniXia, a new reverse osmosis (RO) water treatment system for haemodialysis. It was unveiled at the European Renal Association (ERA) Congress 2025 in Vienna, Austria. The system has been developed with input from dialysis technicians and healthcare staff and is designed to support consistent permeate production, resource efficiency and ease […] The post NIPRO introduces LiniXia water treatment system f…Read Article

Astellas selects Veeva Vault CRM as global commercial platform - Pharmafile

Astellas has selected Veeva Vault CRM as its global customer relationship management (CRM) platform, with Veeva China CRM deployed specifically for operations in China. The move is intended to support commercial agility and strengthen execution across markets. The announcement reflects Astellas’ broader digital transformation strategy as it scales its global operations. “Having a foundation for […] The post Astellas selects Veeva Vault CRM as gl…China · ChinaRead Article

Evosep launches high-throughput proteomics platform Evosep Eno - Pharmafile

Evosep has launched Evosep Eno, a new high-throughput separation platform designed to support next-generation workflows in liquid chromatography-mass spectrometry (LC-MS)-based proteomics. The tool was introduced at the 2025 ASMS conference in Baltimore, US, and aims to increase standardisation, scalability and reproducibility in large-scale protein analysis. The platform enables analysis of up to 500 samples per […] The post Evosep launches hig…Baltimore, MD · BaltimoreRead Article

LEO Pharma initiates phase 2a trial of delgocitinib cream for rare skin condition - Pharmafile

LEO Pharma has initiated a phase 2a trial investigating delgocitinib cream in adults with mild-to-severe palmoplantar pustulosis (PPP). The DELTA NEXT study will analyse the efficacy and safety of the therapy compared with cream vehicle across sites in the US, UK, Germany, Poland and Canada. PPP is a chronic, relapsing inflammatory skin condition characterised by […] The post LEO Pharma initiates phase 2a trial of delgocitinib cream for rare ski…United States · United StatesRead Article

Ochre Bio appoints Elaine Sullivan as senior independent non-executive director - Pharmafile

Ochre Bio has appointed Elaine Sullivan as senior independent non-executive director. She joins the Oxford-based RNA therapeutics company with a wealth of experience in global pharma R&D and strategic leadership. Sullivan previously served as vice president of global external R&D at Eli Lilly, where she managed a $100m portfolio, and as vice president at AstraZeneca, […] The post Ochre Bio appoints Elaine Sullivan as senior independent non-execu…Oxford, England · OxfordRead Article

NICE Recommends Mirikizumab (Omvoh ▼) for Previously Treated Moderately to Severely Active Crohn's Disease 1 - Pharmafile

100% Center coverage: 1 sources
In the Phase 3 VIVID-1 trial, patients treated with mirikizumab experienced significant improvement in clinical remission and endoscopic response at one year 2 Among those who achieved endoscopic response at one year, 88% of patients maintained endoscopic response at two years of continuous mirikizumab treatment in open-label extension 3 BASINGSTOKE, May 30, 2025 – Today, […] The post NICE recommends mirikizumab (Omvoh ▼) for previously treated …Eli Lilly · BasingstokeSee the Story

Ryvu Therapeutics appoints Justyna Żółtek to management board - Pharmafile

Ryvu Therapeutics has promoted Justyna Żółtek, chief people officer, to its management board. The appointment reflects the company’s focus on organisational development as it continues to advance a pipeline of oncology programmes. Żółtek joined Ryvu in 2021, leading the creation of its human resources (HR) function during a period of operational growth. Since then, she […] The post Ryvu Therapeutics appoints Justyna Żółtek to management board ap…Kraków · KrakówRead Article

Neogap Receives Approval to Administer Full Dose in Cell Therapy Trial for Colorectal Cancer - Pharmafile

Neogap Therapeutics has received regulatory approval from the Swedish Medical Products Agency to administer the full dose of its investigational cell therapy to all patients in its ongoing phase 1 and 2 trial for advanced colorectal cancer. The approval allows for a revised study protocol that removes the initial dose-escalation step, allowing all participants to […] The post Neogap receives approval to administer full dose in cell therapy trial…Houston, Texas · HoustonSee the Story

TQ Therapeutics acquires Juno GmbH to support decentralised cell therapy platform

TQ Therapeutics (TQx) has acquired Juno Therapeutics GmbH, the German subsidiary of Juno Therapeutics, through a share purchase agreement. Juno GmbH was previously owned by Bristol Myers Squibb. Financial terms have not been disclosed. The acquisition expands TQx’s access to intellectual property and licensing agreements that will support the development of its decentralised, automated cell […]Germany · GermanySee the Story

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