Mitochondrial Complexity Is Regulated at ER-Mitochondria Contact Sites via PDZD8-FKBP8 Tethering

Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering

Mitochondria-ER membrane contact sites (MERCS) represent a fundamental ultrastructural feature underlying unique biochemistry and physiology in eukaryotic cells. The ER protein PDZD8 is required for the formation of MERCS in many cell types, however, its tethering partner on the outer mitochondrial membrane (OMM) is currently unknown. Here we identify the OMM protein FKBP8 as the tethering partner of PDZD8 using a combination of unbiased proximi…

Evidence Against Mitochondrial Mutator Mice as Support for the Importance of Mitochondrial DNA Damage

One of the major challenges in aging research is establishing the relative importance of the various well-known different mechanisms, hallmarks, and dysfunctions of aging. This is large part because biological systems and their relationships to one another are not fully mapped and understood at the detail level. Mitochondrial dysfunction is a great example; mitochondria are enormously complex, and even very important processes such as mitophagy …