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Top fightaging.org News

Vitamin D supplements may slow aging: Study
Medical · United States

Vitamin D supplements may slow aging: Study

Coverage: 23 sources
See the Story
Research Uncovers New Links Between Blood Lipid Profiles and Risk of Developing Alzheimer's
Alzheimer's Disease

Research Uncovers New Links Between Blood Lipid Profiles and Risk of Developing Alzheimer's

68% Center coverage: 22 sources
People who are at higher risk for heart disease also seem more likely to develop dementia.See the Story
Better Brain Care Score Linked to Lower Risk of Heart Disease and Cancer
Cancer · Boston

Better Brain Care Score Linked to Lower Risk of Heart Disease and Cancer

Coverage: 2 sources
A new study from researchers at Mass General Brigham has found that a higher McCance Brain Care Score not only associates with the risk of brain-related conditions such as stroke, dementia, and depression but also strongly associates with developing cardiovascular disease and three common types of cancer.See the Story

Mitochondrial Complexity Is Regulated at ER-Mitochondria Contact Sites via PDZD8-FKBP8 Tethering

100% Center coverage: 1 sources
Mitochondria-ER membrane contact sites (MERCS) represent a fundamental ultrastructural feature underlying unique biochemistry and physiology in eukaryotic cells. The ER protein PDZD8 is required for the formation of MERCS in many cell types, however, its tethering partner on the outer mitochondrial membrane (OMM) is currently unknown. Here we identify the OMM protein FKBP8 as the tethering partner of PDZD8 using a combination of unbiased proximi…See the Story

Sustained Midlife Weight Loss in Overweight Individuals Correlates with Reduced Incidence of Later Age-Related Disease

An extensive literature of epidemiology demonstrates that being overweight correlates with increased age-related disease, increased medical expenditure, and increased mortality. The greater the excess weight, the worse the outcome. While human studies can largely only uncover correlations between lifestyle choice and health, animals studies convincingly demonstrate that carrying too much visceral fat is disruptive to health and life span. Viscer…Helsinki · HelsinkiRead Article

Calorie Restriction Improves Measures of Ovarian Aging in Non-Human Primates

Calorie restriction is well known to slow aging in mammals. Short-term improvements in metabolism are fairly similar across mammalian species, but short-lived mammals show a much greater extension of life span in response to calorie restriction than is the case in long-lived mammals such as our own species. Why this is the case remains to be determined, but one might suspect that the answer lies somewhere in the still incompletely cataloged deta…Read Article

A New Pace of Aging Built From Clinical Measures

The original Pace of Aging that emerged from analysis of Dunedin Study data was a form of epigenetic clock. Here, what the researchers are calling Pace of Aging is instead a form of aging clock derived from clinical chemistry and other simple measures of function such as grip strength. Further, it was generated from data obtained from different study populations. It is not the same at all! There is nothing in common between these assessments. It…United States · United StatesRead Article

Silent X Chromosome Activation as a Contribution to Sex Differences in Aging

Regulation of gene expression is a matter of control over the structure of packaged nuclear DNA, determining which regions are accessible to transcription proteins. This control becomes dysfunctional with age. Evidently there will be sex differences in the outcomes of this dysfunction because males and females have different chromosomes. It remains an open question as to which of these classes of difference are important in male versus female li…Regulation · MunichRead Article

Therapeutic Plasma Exchange Reduces Epigenetic Age Acceleration in Some Clocks

Researchers have been generating aging clocks for going on twenty years now, and as one might expect there are now lot of these clocks. Even just counting the epigenetic clocks one has a great deal of choice. Most studies that make use of clocks choose to assess only a few of the more prominent options, but as today's report on a clinical trial of therapeutic plasma exchange makes clear, the right way to go about this is to assess every single c…San Francisco, California · San FranciscoRead Article

One Measure of Brain Age May Be Insufficient

The brain is a complex organ. In this era of aging clocks, a number of approaches have been developed to assess the biological age of the brain from neuroimaging and other data. Is one metric for brain age sufficient, however? Here researchers present evidence for different portions of the brain to undergo age-related change at different rates. The researchers correlate their novel imaging-based models of brain aging to measures of cognitive per…Read Article

Reviewing What is Known of Epigenetic Changes in Aged T Cells

Immune system function declines with age. Immune cells become more inflammatory, but at the same time less capable. Further, populations of malfunctioning and harmful immune cells grow in number. The immune system is enormously complex, and one might argue that this is the primary reason why researchers have yet to produce a full accounting of the details of immune aging. Producing data is straightforward, but connecting the many different views…Read Article

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