Tuning Charge Density of Chimeric Antigen Receptor Optimizes Tonic Signaling and CAR-T Cell Fitness

Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

Tonic signaling of chimeric antigen receptor (CAR), i.e., the spontaneous CAR activation in the absence of tumor antigen stimulation, is considered to be a pivotal event controlling CAR-T efficacy. However, the molecular mechanism underlying the spontaneous CAR signals remains elusive. Here, we unveil that positively charged patches (PCPs) on the surface of the CAR antigen-binding domain mediate CAR clustering and result in CAR tonic signaling. …

Evidence of CAR T-cell therapy against cancers presented at US conference

Evidence of CAR T-cell therapy against cancers presented at US conference

New CAR T Vision Coalition and roadmap report to launch at ASCO aims to double patients treated with CAR T-cell therapy by 2030 - Pharmafile

For people living with aggressive blood cancers, CAR T-cell therapy offers hope for a longer, healthier life, and for some, the opportunity for cure. Yet currently only ~2 out of 10 people in the US and ~3 out of 10 people in Europe with advanced blood cancers get access to CAR T. To address barriers […] The post New CAR T Vision Coalition and roadmap report to launch at ASCO aims to double patients treated with CAR T-cell therapy by 2030 appear…

Harnessing AI in Cell and Gene Therapy: Advances in CAR-T Therapies - BioPatrika

Cell and gene therapies are at the forefront of biotech innovation, offering groundbreaking treatments like CAR-T cell immunotherapies, viral vector-based gene therapies, and CRISPR gene editing for previously intractable diseases. These advanced therapies are highly complex. CAR-T cell products are living cells engineered for each patient, gene therapies rely on delicate viral delivery systems, and […] The post Harnessing AI in Cell and Gene Th…