ZBTB46 Is a Shear-Sensitive Transcription Factor Inhibiting Endothelial Cell Proliferation via Gene Expression Regulation of Cell Cycle Proteins

ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins

ZBTB46 is a transcription factor identified in classical dendritic cells and keeps dendritic cells in a quiescent state. Chromatin immunoprecipitation sequencing in dendritic cells has identified over 1300 potential gene targets of ZBTB46, affecting many processes including cell cycle. Endothelial cells (ECs) also express ZBTB46 and are mostly in a quiescent non-proliferative state. While EC proliferation is a critical process in development, dy…

Atherosclerosis Shows Tumor-Like Cell Growth, Surprising Scientists

A new study shows that cells in atherosclerotic blood vessels grow in a way that resembles tumor development. This finding offers new biological insights and could lead to new treatment strategies. Researchers from the University of Southern Denmark and Odense University Hospital have studied tissue from patients with atherosclerosis. They found that many of the [...]