US EditionDiscovery provides crucial molecular targets for future obesity treatments
13 Articles
13 Articles
Science Daily
Medical XpressScientists discover why obesity takes away the pleasure of eating
Many obese people report losing pleasure in eating rich foods -- something also seen in obese mice. Scientists have now discovered the reason. Long-term high-fat diets lower levels of neurotensin in the brain, disrupting the dopamine pleasure network and decreasing the desire to eat high-fat foods. Raising neurotensin levels in mice brings back the pleasure and aids weight loss. Bringing back the pleasure could help people break the habit of ove…
Discovery provides crucial molecular targets for future obesity treatments
The pleasure we get from eating junk food - the dopamine rush from crunching down on salty, greasy French fries and a luscious burger - is often blamed as the cause of overeating and rising obesity rates in our society.
Changes in neurotensin signalling drive hedonic devaluation in obesity
Calorie-rich foods, particularly those that are high in fat and sugar, evoke pleasure in both humans and animals1. However, prolonged consumption of such foods may reduce their hedonic value, potentially contributing to obesity2–4. Here we investigated this phenomenon in mice on a chronic high-fat diet (HFD). Although these mice preferred high-fat food over regular chow in their home cages, they showed reduced interest in calorie-rich foods in a…
Coverage Details
Bias Distribution
- 75% of the sources are Center
To view factuality data please Upgrade to Premium
Ownership
To view ownership data please Upgrade to Vantage
