US EditionUpstream open reading frames buffer translational variability during Drosophila evolution and development
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Upstream open reading frames buffer translational variability during Drosophila evolution and development
Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown. Upstream open reading frames (uORFs) are widespread cis-regulatory elements in eukaryotic genomes that regulate translation, but it remains unclear whether and how uORFs contribute to stabilizing protein levels. In this study, we performed ribosome translation simulati…
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