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Top elifesciences.org News

From Nigeria to Pakistan, TB Testing 'in a Coma' After U.S. Aid Cuts
South Africa · South Africa

From Nigeria to Pakistan, TB Testing 'in a Coma' After U.S. Aid Cuts

80% Right coverage: 5 sources
Moves by U.S. President Donald Trump have stalled vital research in South Africa and left TB survivors lacking support in India.See the Story
Genetic Deep Dive Dispels Fear of Hybrid Worm Threat
Environment

Genetic Deep Dive Dispels Fear of Hybrid Worm Threat

67% Center coverage: 3 sources
Parasitic worms that infect humans are not interbreeding with those that infect cattle as previously thought. This is good news for when it comes to controlling schistosomiasis, a disease caused by these worms that affects more than 200 million people globally.See the Story
Upstream open reading frames buffer translational variability during Drosophila evolution and development
Species

Upstream open reading frames buffer translational variability during Drosophila evolution and development

Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown. Upstream open reading frames (uORFs) are widespread cis-regulatory elements in eukaryotic genomes that regulate translation, but it remains unclear whether and how uORFs contribute to stabilizing protein levels. In this study, we performed ribosome translation simulati…Read Article

A general mechanism for initiating the bacterial general stress response

The General Stress Response promotes survival of bacteria in adverse conditions, but how sensor proteins transduce species-specific signals to initiate the response is not known. The serine/threonine phosphatase RsbU initiates the General Stress Response in Bacillus subtilis upon binding a partner protein (RsbT) that is released from sequestration by environmental stresses. We report that RsbT activates RsbU by inducing otherwise flexible linker…Read Article

Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles

The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, the involvements of DA release, real-time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumbens (NAc) shell in pair bonding remain unclear. This work verified that male mandarin voles after pair bonding released higher levels of DA in the NAc shell and displayed higher levels of D1 MSNs activity and low…Read Article

Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer

Trastuzumab resistance remains a challenge for HER2-positive breast cancer treatment. Targeting metabolic reprogramming would provide novel insights for therapeutic strategies. Here, we integrated metabolomics, transcriptomics, and epigenomics data of trastuzumab-sensitive and primary-resistant HER2-positive breast cancer to identify metabolic alterations. Aberrant cysteine metabolism was discovered in trastuzumab primary-resistant breast cancer…Breast CancerRead Article

Correction: Dietary nitrate supplementation prevents radiotherapy-induced xerostomia

Read Article

A ventral hippocampal-lateral septum pathway regulates social novelty preference

The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability to recognize kin and familiar individuals and engage in appropriate behaviors is associated with several types of dementia, including Alzheimer’s disease. Mice preferentially spend more time investigating a novel individual relative to a familiar individual. Yet, how social novelty-related information driv…Read Article

Pathway activation model for personalized prediction of drug synergy

Targeted monotherapies for cancer often fail due to inherent or acquired drug resistance. By aiming at multiple targets simultaneously, drug combinations can produce synergistic interactions that increase drug effectiveness and reduce resistance. Computational models based on the integration of omics data have been used to identify synergistic combinations, but predicting drug synergy remains a challenge. Here, we introduce Drug synergy Interact…Cancer · GroningenSee the Story

Interferon Signaling: Immobilizing bacteria to prevent infections

The interferon-induced GTPase GVIN1 prevents bacteria from spreading among cells by coating them and rendering them immobile.Read Article

HNF4α-TET2-FBP1 Axis Contributes to Gluconeogenesis and Type 2 Diabetes

The control of gluconeogenesis is critical for glucose homeostasis and the pathology of type 2 diabetes (T2D). Here, we uncover a novel function of TET2 in the regulation of gluconeogenesis. In mice, both fasting and a high-fat diet (HFD) stimulate the expression of TET2, and TET2 knockout impairs glucose production. Mechanistically, FBP1, a rate-limiting enzyme in gluconeogenesis, is positively regulated by TET2 in liver cells. TET2 is recruite…United States · United StatesSee the Story

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