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Top elifesciences.org News

Phase Separation Organizes the Site of Autophagosome Formation

Phase Separation Organizes the Site of Autophagosome Formation

100% Center coverage: 1 sources
Many biomolecules undergo liquid–liquid phase separation to form liquid-like condensates that mediate diverse cellular functions1,2. Autophagy is able to degrade such condensates using autophagosomes—double-membrane structures that are synthesized de novo at the pre-autophagosomal structure (PAS) in yeast3–5. Whereas Atg proteins that associate with the PAS have been characterized, the physicochemical and functional properties of the PAS remain …See the Story
Omidenepag Promising Against Glaucoma in Real-World Study
Medical

Omidenepag Promising Against Glaucoma in Real-World Study

Eye drops containing 0.002% omidenepag isopropyl can safely reduce intraocular pressure in patients with newly diagnosed primary open-angle glaucoma, according to a real-world study.See the Story
Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum show a containment strategy for toxic intermediates

Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum show a containment strategy for toxic intermediates

Clostridium thermocellum, a cellulolytic thermophilic anaerobe, is considered by many to be a prime candidate for the realization of consolidated bioprocessing (CBP) and is known as an industry standard for biofuel production. C. thermocellum is among the best biomass degraders identified to date in nature and produces ethanol as one of its main products. Many studies have helped increase ethanol titers in this microbe; however, ethanol producti…Read Article

Neurons throughout the brain embed robust signatures of their anatomical location into spike trains

Neurons in the brain are known to encode diverse information through their spiking activity, primarily reflecting external stimuli and internal states. However, whether individual neurons also embed information about their own anatomical location within their spike patterns remains largely unexplored. Here, we show that machine learning models can predict a neuron’s anatomical location across multiple brain regions and structures based solely on…United States · United StatesRead Article

Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

Patients with microsatellite stable/low microsatellite instability mismatch repair-proficient metastatic colorectal cancer may be sensitive to tislelizumab treatment after receiving Gamma Knife stereotactic radiotherapy.CancerRead Article

Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

Tissue-resident memory T cells (TRM) protect from repeat infections within organs and barrier sites. The breadth and duration of such protection are defined at minimum by three quantities: the rate at which new TRM are generated from precursors, their rate of self-renewal, and their rate of loss through death, egress, or differentiation. Quantifying these processes individually is challenging. Here we combine genetic fate mapping tools and mathe…Read Article

Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

Salmonella Dublin is a host-adapted, invasive nontyphoidal Salmonella (iNTS) serovar that causes bloodstream infections in humans and demonstrates increasing prevalence of antimicrobial resistance (AMR). Using a global dataset of 1303 genomes, coupled with in vitro assays, we examined the evolutionary, resistance, and virulence characteristics of S. Dublin. Our analysis revealed strong geographical associations between AMR profiles and plasmid t…Australia · AustraliaRead Article

Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas Foxg1 represses an electrosensory fate

In electroreceptive jawed fishes and amphibians, individual lateral line placodes form lines of neuromasts on the head containing mechanosensory hair cells, flanked by fields of ampullary organs containing electroreceptors - modified hair cells that respond to weak electric fields. Extensively shared gene expression between neuromasts and ampullary organs suggests that conserved molecular mechanisms are involved in their development, but a few t…Read Article

mirror determines the far posterior domain in butterfly wings

Insect wings, a key innovation that contributed to the explosive diversification of insects, are recognized for their remarkable variation and many splendid adaptations. Classical morphological work subdivides insect wings into several distinct domains along the anteroposterior (AP) axis, each of which can evolve relatively independently to produce the myriad forms we see in nature. Important insights into AP subdivision of insect wings come fro…InnovationRead Article

Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway

Nodaviridae infections cause severe mortality in insects and fish, with nervous necrosis virus (NNV) posing significant threats to global fish populations. However, the host factors involved in NNV entry remain poorly understood. We identify myosin light chain 3 from marine medaka (Oryzias melastigma) (MmMYL3) as a novel receptor for red-spotted grouper NNV (RGNNV), facilitating internalization via macropinocytosis. MmMYL3 directly binds the RGN…FishRead Article

Learning and cognition in highspeed decision making

It is widely accepted that more time and information yield better decisions. However, some decisions manage to be extremely fast and yet accurate. The trick of such highspeed decisions appears to be the use of simplifying heuristics that works well for the most common condition but lacks flexibility otherwise. Here, we describe an unexpected level of flexibility in a complex highspeed decision that is made faster than an Olympic sprinter can res…Read Article

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