Unlocking efficiency in real-world collaborative studies: a multi-site international study with one-shot lossless GLMM algorithm

Unlocking efficiency in real-world collaborative studies: a multi-site international study with one-shot lossless GLMM algorithm

The widespread adoption of real-world data has given rise to numerous healthcare-distributed research networks, but multi-site analyses still face administrative burdens and data privacy challenges. In response, we developed a Collaborative One-shot Lossless Algorithm for Generalized Linear Mixed Models (COLA-GLMM), the first-ever algorithm that achieves both lossless and one-shot properties. COLA-GLMM ensures accuracy against the gold standard …