New model to study hypertension and aortic aneurysms developed

Mitochondrial NAD+ deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm

Thoracic and abdominal aortic aneurysm poses a substantial mortality risk in adults, yet many of its underlying factors remain unidentified. Here, we identify mitochondrial nicotinamide adenine dinucleotide (NAD)⁺ deficiency as a causal factor for the development of aortic aneurysm. Multiomics analysis of 150 surgical aortic specimens indicated impaired NAD+ salvage and mitochondrial transport in human thoracic aortic aneurysm, with expression o…

New model to study hypertension and aortic aneurysms developed

Investigators have discovered a new pathway that may lead to a treatment for high blood pressure and aortic aneurysms. By creating a new laboratory model for studying these conditions, the team treated hypertension and aortic aneurysms by targeting a protein that they discovered to be involved in the vascular cells' response to oxidative stress.

Scientists develop a new model to study hypertension and aortic aneurysms

Oxidative stress can occur when our cells are exposed to harmful molecules called "reactive oxygen species" over time. These reactive oxygen species can damage cells and are found in important disease states, such as high blood pressure and aortic aneurysms. Aortic aneurysms are balloon-like swellings of the body's largest artery and are often fatal when the aneurysm bursts.

JCI Differential aortic aneurysm formation provoked by chemogenetic oxidative stress

Aortic aneurysms are potentially fatal focal enlargements of the aortic lumen; the disease burden is increasing as the human population ages. Pathological oxidative stress is implicated in the development of aortic aneurysms. We pursued a chemogenetic approach to create an animal model of aortic aneurysm formation using a transgenic mouse line, DAAO-TGTie2, that expresses yeast d-amino acid oxidase (DAAO) under control of the endothelial Tie2 pr…

CX 2025: Managing blood pressure with medical therapy may play a role in limiting AAA growth - Cardiovascular News

Colin Bicknell Results from the Central blood pressure and variability evaluation in abdominal aortic aneurysm (AAA), or CAVE-ON, study, which sought to measure the impact of blood pressure control on AAA growth rates, found no significant association between growth and central blood pressure variability. The data were delivered as a podium-first during a CX abdominal aortic challenges session on Thursday afternoon. The prospective longitudinal …