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ScienceSomatically acquired mutations in the E1 ubiquitin-activating enzyme UBA1 within hematopoietic stem and progenitor cells (HSPCs) were recently identified as the cause of the adult-onset autoinflammatory syndrome VEXAS (vacuoles, E1 enzyme, X linked, autoinflammatory, somatic)1. UBA1 mutations in VEXAS lead to clonal expansion within the HSPC and myeloid, but not lymphoid, compartments. Despite its severity and prevalence, the mechanisms whereby …See the Story
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
100% Center coverage: 2 sources
ObesityThere's some good news regarding obesity rates in the US: New survey data shows 37 percent of US adults are currently classed as obese, down from a record high of 39.9 percent in 2022. And there seems to be one major reason why. The findings are based on an online survey of 16,946 US adults conducted by the data analytics firm Gallup in the first three quarters of 2025. This equates to around 7.6 million fewer people being counted as obese compa…See the Story
US Obesity Rates Have Dropped, And GLP-1 Drugs May Explain Why
100% Center coverage: 1 sources
