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Top jci.org News
CancerThe Cockayne Syndrome B (CSB, ERCC6) protein, interacts with the exonuclease SNM1A
during transcription-coupled DNA interstrand (ICL) repair, with CSB facilitating localisation of
SNM1A to ICL damage. The functional and mechanistic details of this interaction in DNA
repair, however, have not b...See the Story
Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease
HIV · United StatesBack in 2021, this woman found out that she’s HIV positive, and she has no idea who gave this to her. But ever since she was diagnosed, it’s been eye-opening to her how people are largely ignorant regarding HIV. She’s come to understand that the lack of information people have about HIV, coupled with the […]See the Story
She Has HIV And Her Friend Freaked Out On Her, Then Blocked Her After She Disclosed It
United States · United StatesDelivering a lab-made version of the missing enzyme in Sanfilippo syndrome type D directly into the brain reduced toxic heparan sulfate buildup, a key Sanfilippo event, and eased signs of inflammation in a mouse model of the disease, a new study reports. These benefits were observed even when the treatment was given on a schedule designed to mimic a real-world regimen in patients, “demonstrating preclinical efficacy for [Sanfilippo syndrome type…See the Story
