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Apollo Hospitals Ahmedabad Secures Fourth Consecutive JCI Accreditation - Express Healthcare

Apollo Hospitals, Ahmedabad, has received Joint Commission International (JCI) accreditation for the fourth consecutive cycle, reaffirming its compliance with over 1,000 standards related to clinical care, infrastructure, operational processes and staff competence. The hospital first obtained JCI accreditation in 2016 and has since sustained adherence to the requirements of one of the most stringent international evaluations in healthcare. JCI a…See the Story

JCI Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis–induced cytokine transcriptional responses

Immune and clinical outcomes to Mycobacterium tuberculosis (Mtb) infection vary greatly between individuals, yet the underlying genetic and cellular mechanisms driving this heterogeneity remain poorly understood. We performed a cellular genome-wide association study to identify genetic variants associated with Mtb-induced monocyte transcriptional expression of IL1B, IL6, TNF, and IFNB1 via RNA-Seq in a Ugandan cohort. Significantly associated va…Tuberculosis · Uganda See the Story

JCI Mutant THAP11 causes cerebellar neurodegeneration and triggers TREM2-mediated microglial activation in mice

Abnormal expansions of the CAG trinucleotide repeat within specific gene exons give rise to polyglutamine (polyQ) diseases, a family of inherited disorders characterized by late-onset neurodegeneration. Recently, a new type of polyQ disease was identified and named spinocerebellar ataxia 51 (SCA51). SCA51 is caused by polyQ expansion in THAP domain containing 11 (THAP11), an essential transcription factor for brain development. The pathogenesis …United States · United States See the Story

JCI The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology

Purine nucleotides are critical for nucleic acid synthesis, signaling, and cellular metabolism. Thiopurines (TPs), including 6-mercaptopurine and 6-thioguanine, are cornerstone agents for the treatment of acute lymphoblastic leukemia (ALL). TP efficacy and cytotoxicity depend on the metabolism and intracellular activation of TPs, a process influenced by pharmacogenes such as thiopurine-S methyltransferase (TPMT) and NUDIX (nucleoside diphosphate…Read Article

JCI What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment

The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is composed of a dense stromal compartment and is poorly vascularized, resulting in limited nutrient delivery. As a result, PDAC cells must adapt to cope with the metabolic stresses brought on by TME nutrient limitation. In this article, we first review recent studies that have provided quantitative measurements of nutrient levels in the PDAC TME. These studies have prov…Read Article

JCI Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection

Graft endothelial cells (ECs) express donor alloantigens and encounter cytotoxic T lymphocytes (CTLs) but are generally spared during T cell–mediated rejection (TCMR), which predominantly affects epithelial structures. The mechanisms underlying this vascular immune privilege are unclear. Transcriptomics analyses and endothelial-mesenchymal transition assessments confirmed that the graft endothelium was preserved during TCMR. Coculture experiment…United States · United States Read Article

JCI Corrigendum to Targeting apoptotic pathways for cancer therapy

United States · United States Read Article

JCI Metastatic heterogeneity in pancreatic cancer: mechanisms and opportunities for targeted intervention

Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal cancers, with metastasis as the primary driver of mortality. While metastatic mechanisms are shared across malignancies, PDAC metastasis poses unique therapeutic challenges due to the presence of extensive tumor heterogeneity, desmoplasia, and immunosuppression — features that enable diverse migratory behaviors and therapeutic resistance. Recent advances have shown that metast…Read Article

JCI An approach to targeting Nav1.7 for pain sensations

Pain is a serious medical condition with current treatments remaining limited by side effects. The Nav1.7 voltage-gated sodium channel is a crucial determinant of nociceptor excitability and a promising target for nonaddictive analgesics. However, development of blockers has been difficult. In this issue of the JCI, Singh, Bernabucci, and authors identify a strategy for reducing Nav1.7 currents. These findings identify fibroblast growth factor 1…Read Article

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