US EditionGlow-in-the-Dark Axolotls Reveal a Clue in the Mystery of Limb Regeneration
- Professor James Monaghan and his team at Northeastern University published a study on Tuesday, June 10, 2025, revealing how axolotls regenerate limbs using retinoic acid signaling.
- They investigated axolotls because these aquatic salamanders can regrow limbs quickly, and understanding this process could help humans regrow body parts in the future.
- Monaghan’s team used genetically engineered glowing axolotls to trace how retinoic acid acts as a signal to fibroblasts, which control regeneration and determine the limb's size and shape.
- Monaghan stated that they identified specific enzymes responsible for degrading retinoic acid, which allows for controlled limb regeneration without resulting in extra limb growth.
- The findings mark significant progress toward regenerative medicine, suggesting future therapies might activate similar biological programs to regrow human limbs or heal wounds without scarring.
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By Kameryn Griesser, CNN A tiny creature with gills, a smile and bright green skin has just given scientists a key clue to solving one of biology's biggest mysteries: limb regeneration. Aquatic salamanders called axolotls are known for their unusual ability to regenerate limbs lost to injury or amputation. Now, researchers have learned more about the complex process behind this superpower in a new study published Tuesday in Nature Communications.
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