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Genetic Analyses of Early-Onset Alzheimer’s Disease Using Next Generation Sequencing

Summary by Nature
Alzheimer’s disease (AD) is the most common type of neurodegenerative dementia, but the cause of AD remained poorly understood. Many mutations in the amyloid precursor protein (APP) and presenilin 1 and 2 (PSEN1 and PSEN2) have been reported as the pathogenic causes of early-onset AD (EOAD), which accounts for up to 5% of all AD cases. In this study, we screened familiar/de novo EOAD (n = 67) samples by next-generation sequencing (NGS) of a 50-g…

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A new study gives great hope. Researchers have developed a test that can predict the age of the disease in Alzheimer's dementia.

At a given moment, we all entered a room with a specific purpose and we completely forgot what we were going to do, says Professor Scott Small, director of the Boli Alzheimer's Research Centre at Columbia University, counting how people can figure out if they are sick.

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hcplive.com broke the news in on Friday, July 4, 2025.
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