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Bristol Myers Squibb signs $11bn cancer drug deal with BioNTech

  • Bristol Myers Squibb signed a global co-development and co-commercialization deal with BioNTech in 2025 to jointly develop an investigational bispecific antibody called BNT327.
  • The deal followed BioNTech's progress in developing BNT327, a PD-L1xVEGF bispecific antibody now in Phase 3 trials for extensive-stage small cell lung cancer, with triple-negative breast cancer trials planned.
  • Bristol Myers Squibb has committed an initial $1.5 billion to BioNTech, with additional guaranteed anniversary payments totaling up to $2 billion through 2028, and potential milestone payments reaching $7.6 billion, while both parties will equally share the costs and profits related to development and commercialization.
  • BNT327 aims to succeed Opdivo, whose market exclusivity may expire in 2028, as Bristol Myers Squibb's CEO Christopher Boerner said the partnership will accelerate clinical trials and expand indications.
  • The collaboration signals Bristol Myers Squibb's commitment to bispecific antibody immunotherapy as a potential new standard for solid tumors, while reflecting a costly investment in a competitive oncology market.
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For the development of cancer therapies, the Mainz-based company is allied with the US company Bristol Myers Squibb. This could bring Biontech billions.

·Munich, Germany
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biopharmadive.com broke the news in on Monday, June 2, 2025.
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