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Early Warning Signs of Vision Loss From Brain Disorder Identified

Researchers created a scoring system identifying papilledema severity and retinal changes as key predictors of lasting vision problems in idiopathic intracranial hypertension patients.

  • On October 29, 2025, researchers published in Neurology an assessment to help physicians predict vision problems in people with intracranial hypertension at diagnosis.
  • Idiopathic intracranial hypertension often develops without symptoms, causing chronic headaches and vision problems, with obesity as the primary risk factor and untreated cases risking vision loss, study author Dagmar Beier, MD noted.
  • The study involved 154 people with intracranial hypertension , including 147 people with papilledema; 69% had scotomas and 26% had reduced visual acuity.
  • Researchers found two mechanisms causing vision problems: one linked higher papilledema to optic nerve fiber layer thinning and scotomas, another involved severe papilledema with macula issues; follow-up showed 50% had scotomas, 13% reduced acuity, none blinded.
  • Beier cautioned that the study's limitations include the need for external validation, as she said, `'This score needs to be validated by external groups before it can be considered ready for use, but we identified the severity of papilledema and the disorganization of the inner layer of the retina as major predictors for who will have persistent vision problems.
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Medical Xpress broke the news in on Wednesday, October 29, 2025.
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