The Spatial and Temporal Activation of Macrophages During Fibrosis

The spatial and temporal activation of macrophages during fibrosis

Macrophages are active participants of tissue repair and when normal repair processes fail, fibrosis can ensue, which leads to major organ dysfunction and affects nearly a billion people worldwide. Here we focus on macrophages in the spatiotemporal control of fibrosis, drawing on our understanding of the roles of these cells in organogenesis, adult organ homeostasis and wound repair. We describe recent insights from single-cell transcriptomics s…

University of Sunderland researchers’ promising new approach to treating liver fibrosis

An experimental new treatment developed by a team of University of Sunderland researchers is showing early promise in the fight against a potentially deadly liver disease.Liver fibrosis is a serious and often silent condition that affects around 2 million people in the UK.It happens when the liver becomes damaged – often due to long-term issues like alcohol use, obesity or chronic infections – and starts to develop scar tissue. Over time, that s…