IL-22BP Is Regulated by the Inflammasome and Modulates Tumorigenesis in the Intestine

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

IL-22 is one of the factors that, although important for wound healing, also promote tumorigenesis; the regulation of IL-22BP, the IL-22 binding protein, via the NLRP3 and NLRP6 inflammasomes provides an unanticipated mechanism, controlling IL-22 and thereby the development of colon cancer. IL-22-binding protein (IL-22BP) is a soluble receptor that specifically binds to and neutralizes the cytokine interleukin (IL) 22, but its physiological func…

Two tiny targets, one giant leap toward a cancer cure

A UNIGE team has identified two new proteins that regulate gene expression, a discovery that could pave the way for new cancer treatments.