Treating chronic inflammatory diseases with JAK inhibitors

Treating chronic inflammatory diseases with JAK inhibitors

Janus kinase inhibitors (JAKis) are an important treatment option for people with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, Crohn's disease or ulcerative colitis. Since their approval, the indications for these medical drugs have steadily increased, but recently safety concerns have also been raised. In order to support the safe and efficient use of JAK inhibitors in the treatment of patients, an international panel …

Urea Skincare May Help Conditions Like Psoriasis and Eczema—Here's How To Use It

Medically reviewed by Casey Gallagher, MDJulPo / Getty ImagesUrea is a compound often added to skincare products. It has hydrating and exfoliating effects that can help treat dry, flaky, or itchy skin. Products with urea have been shown to help manage skin conditions like eczema, psoriasis, and keratosis. Urea is generally safe for long-term topical use and has a low risk of side effects. However, always make sure to test patch before trying a n…

JCI Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune disease currently with no universally highly effective prevention strategies. Identifying pathogenic immune phenotypes in at-risk populations prior to clinical onset is crucial to establishing effective prevention strategies. Here, we applied multimodal single-cell technologies (mass cytometry and CITE-Seq) to characterize the immunophenotypes in blood from at-risk individuals (ARIs) identified …

Best Ways to Manage It

Living with a chronic disease often means monitoring and tracking your symptoms, such as fatigue. This allows you to identify triggers, such as food and stress. It can also help you detect relapses early when the disease is inactive or in remission. When Crohn’s disease fatigue is getting in the way of your daily life, here are some of the ways you can manage it: Rule out underlying anemia Take the necessary supplements as directed by your heal…