US EditionTissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement
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Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement
Tissue-resident memory T cells (TRM) protect from repeat infections within organs and barrier sites. The breadth and duration of such protection are defined at minimum by three quantities: the rate at which new TRM are generated from precursors, their rate of self-renewal, and their rate of loss through death, egress, or differentiation. Quantifying these processes individually is challenging. Here we combine genetic fate mapping tools and mathe…
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