US EditionPioneering Technology Enables Scalable Production of Human Kidney Organoids
Researchers achieved the first successful integration of human kidney organoids into pig kidneys, maintaining viability and function for up to 48 hours post-transplantation.
- On October 31, 2025, a team led by the Institute for Bioengineering of Catalonia integrated human kidney organoids into pig kidneys and transplanted them back into the same animal.
- Using microaggregation and genetic engineering, researchers developed a scalable method to produce thousands of kidney organoids, aiming to regenerate organs before transplantation, Garreta said.
- In porcine transplant tests, the researchers say organoids remained integrated at 24 and 48 hours, maintained viability, and did not trigger significant immune responses, with the transplanted kidney functioning normally.
- Perfusing organoids within kidneys on perfusion machines allows real-time physiological parameters monitoring, enabling immediate damage detection, and researchers say this advances drug screening and clinical trials.
- Collaboration with INIBIC, ONT, and ISCIII was key to preclinical translation, while EBERS supplied perfusion machines for the work published in Nature Biomedical Engineering.
17 Articles
17 Articles
An international team of researchers, led by Spanish scientists, has created human kidney organoids for the first time, combined them with pig kidneys and then successfully transplanted them into the animal's body.
Pioneering technology enables scalable production of human kidney organoids
A research team led by the Institute for Bioengineering of Catalonia (IBEC) and collaborating with the Biomedical Research Institute of A Coruña (INIBIC), as well as other international research groups, has developed pioneering technology that enables human kidney organoids to be produced in a scalable manner.
Eldiario.es
The study represents a milestone in the field of regenerative and personalized medicine, as it establishes the basis for the use of kidney organoids derived from human stem cells for cell therapy in clinical trials
Human kidney organoids successfully integrated into pig kidneys in transplant study
A research team led by the Institute for Bioengineering of Catalonia (IBEC) and collaborating with the Biomedical Research Institute of A Coruña (INIBIC), as well as other international research groups, has developed pioneering technology that enables human kidney organoids to be produced in a scalable manner.
To Coruña supports the bases of regenerative and personalized medicine of the future. Scientists of the Instituto de Investigación Biomédica coruñés (Inibic-Chuac), dependent on the Xunta, have implanted for the first time a pig ‘mini-riñones’ 3D (tridimensional) formed from human laboratory cells. Specifically, they have transplanted to the animal their own modified kidney with those organoids, which were infused ex vivo (they were introduced i…
An international team of researchers led by the Institute of Bioengineering of Catalonia (IBEC) has succeeded in transplanting pig kidneys modified with human renal organoids into an animal for the first time. Experts say that this technique could be used in the future to adapt and repair organs before transplantation
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