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Belgium Says 52 Babies Born From Sperm Donor with Cancer-Linked Gene

  • Belgian officials confirmed that 52 children were born from a sperm donor carrying a cancer-linked TP53 gene mutation between 2008 and 2017.
  • The case emerged following a 2023 notification from a Danish sperm bank that identified a donor carrying a rare genetic mutation associated with Li-Fraumeni syndrome, which raises the risk of developing cancer.
  • Fourteen Belgian fertility centers acquired this donor’s sperm, with 12 using it in treatments resulting in 50 children, and authorities are tracing affected families amid unclear inheritance rates.
  • Tests found the mutation in 23 of 67 tested children across Europe, with 10 diagnosed with cancers including leukemia and lymphoma, and experts recommend genetic counseling for those affected.
  • This case highlights limits in current genetic screening and has prompted calls for tighter regulation on donor limits to prevent abnormal spread of hereditary diseases.
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E! News broke the news in United States on Thursday, May 29, 2025.
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