Shared Mechanisms Across the Major Psychiatric and Neurodegenerative Diseases

Shared mechanisms across the major psychiatric and neurodegenerative diseases

Several common psychiatric and neurodegenerative diseases share epidemiologic risk; however, whether they share pathophysiology is unclear and is the focus of our investigation. Using 25 GWAS results and LD score regression, we find eight significant genetic correlations between psychiatric and neurodegenerative diseases. We integrate the GWAS results with human brain transcriptomes (n = 888) and proteomes (n = 722) to identify cis- and trans- t…

Several Psychiatric Disorders Share The Same Root Cause, Study Finds

Researchers recently discovered that eight different psychiatric conditions share a common genetic basis.