Research Priorities for an HIV Cure: International AIDS Society Global Scientific Strategy 2021

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they are largely transcriptionally silent, but contain replication-competent virus that drives resurgence of the infection once ART is stopped. With a combinat…

Scientists use mRNA to expose hidden HIV in breakthrough step toward cure

Scientists in Australia have found a new way to expose dormant HIV in human cells using mRNA technology, marking a major step toward a potential cure.