Scientists uncover hints of a potential new cause of stomach cancer

The somatic mutation landscape of normal gastric epithelium

The landscapes of somatic mutation in normal cells inform us about the processes of mutation and selection operative throughout life, providing insight into normal ageing and the earliest stages of cancer development1. Here, by whole-genome sequencing of 238 microdissections2 from 30 individuals, including 18 with gastric cancer, we elucidate the developmental trajectories of normal and malignant gastric epithelium. We find that gastric glands a…

Earliest stages and possible new cause of stomach cancer revealed

Scientists have systematically analyzed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer. The team also uncovered hints of a potential new cause of stomach cancer that needs further research.

Study Reveals Possible New Cause of Stomach Cancer

Get latest articles and stories on Health at LatestLY. The team found that despite regular exposure to the acidic contents of the stomach, the gastric lining is protected from any toxic effects. Health News | Study Reveals Possible New Cause of Stomach Cancer.

Scientists uncover hints of a potential new cause of stomach cancer

For the first time, scientists have systematically analyzed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer.

Stomach ulcers, gastritis and even stomach cancer are often the result of an infection with Helicobacter pylori. If the bacterium remains unrecognized over a long period of time, this can have serious consequences. So far, however, the diagnostic detection is complex and expensive. Researchers at the University of Ulm have...

Analysis reveals earliest stages and potential new causes of stomach c

For the first time, scientists have analysed mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer. The team also uncovered hints of a potential new cause of stomach cancer that needs further research. The team analysed genes from 238 samples of normal, non-cancerous gastric gland tissue from the stomachs of 30 people from Hong Kong, the US, and the UK - 18 of whom had gastric cancer and 12 who did n…