US EditionEarly Life Exposure to PFHxA May Impact Male Brain Development
NETHERLANDS, JUL 3 – Early life exposure to PFHxA caused anxiety-like behaviors and memory deficits in male mice, highlighting potential male brain vulnerability during development, researchers said.
- Researchers at the University of Rochester exposed mice to PFHxA via a mealworm treat given to mothers during gestation and lactation, studying male offspring behavior.
- They carried out the study because, to date, PFHxA—a short-chain PFAS restricted by the EU in 2024—had not undergone testing for its effects on neurodevelopment and behavior in rodent models.
- Male mice exposed to higher PFHxA doses showed mild developmental changes such as decreased activity, increased anxiety-like behaviors, and memory deficits, while females showed no effects.
- Senior author Ania Majewska noted that observing behavioral changes exclusively in male subjects aligns with the pattern seen in various neurodevelopmental conditions that predominantly affect males, suggesting a heightened sensitivity of the male brain to environmental factors during development.
- These findings highlight the need for further research on short-chain PFAS neurotoxicity and underscore the importance of regulating PFHxA exposure to protect developing brains.
17 Articles
17 Articles
Shafaq News - Follow-up: A recent study revealed an unexpected effect of PFHxA, a short-chain PFAS compound, on the neurobehavioral behavior of male mice, opening the door for further research and regulatory review of these substances. Perennial chemicals, known as PFAS, are widespread in many industrial and consumer products around the world due to their unique ability to resist water, oil, and stains. Despite their benefits, these compounds ar…
Early life exposure to PFHxA may impact male brain development
"Forever chemicals" or per- and polyfluoroalkyl substances (PFAS) have been widely used in consumer and industrial products for the better part of a century, but do not break down in the natural environment.
Researchers find 'forever chemicals' impact the developing male brain
"Forever chemicals" or per- and polyfluoroalkyl substances (PFAS) have been widely used in consumer and industrial products for the better part of a century, but do not break down in the natural environment. One PFAS, perfluorohexanoic acid or PFHxA, is made up of a shorter chain of molecules and is thought to have less of an impact on human health.
Coverage Details
Bias Distribution
- 67% of the sources lean Left
Factuality
To view factuality data please Upgrade to Premium
