US EditionEuropean Sperm Donor with Rare TP53 Mutation Linked to 10 Cancer Cases in Children
- In 2024, European researchers identified a sperm donor carrying a rare TP53 gene mutation linked to cancer in at least ten children across eight countries.
- The mutation was uncovered after two families reported childhood cancers, prompting genetic testing of 67 children from 46 families born between 2008 and 2015.
- Twenty-Three children were found to carry the variant, with ten developing cancers such as leukemia and non-Hodgkin lymphoma, conditions associated with Li-Fraumeni syndrome.
- Dr. Kasper explained that back in 2008, detecting this variant would have been nearly impossible, and emphasized that there remain several areas requiring enhancement. He recommended genetic counseling for affected individuals along with regular MRI screenings as part of the follow-up care.
- The case revealed a lack of harmonized European regulation on donor limits and raised calls for continent-wide oversight to prevent similar health risks in the future.
54 Articles
54 Articles
10 of Donor's 67 Offspring Across Europe Have Cancer
Calls to restrict the number of births one donor's sperm can be used to produce have followed the revelation that 10 of 67 children in Europe fathered by a man with a rare mutation have cancer. The problem was discovered when two families separately contacted their fertility clinics after their...
Semen Donation: How a Man Has Massively Transmitted a Predisposition to Cancer
A man with a pathogenic genetic mutation has produced at least 67 children in Europe, ten of whom have developed early cancer. Biologist Edwige Kasper alerts about risks and calls for European legislation.
Prolific sperm donor passes genetic cancer causing mutation to 10 offsprings
Donor fathering 67 babies, carrying an undetected TP53 mutation; 23 of his offspring inherited cancer risk and 10 are diagnosed with leukemia or lymphoma; Israeli legislation to prevent such cases, lacking
Coverage Details
Bias Distribution
- 40% of the sources lean Right
To view factuality data please Upgrade to Premium
Ownership
To view ownership data please Upgrade to Vantage
