US EditionCell's stress response is more nuanced and compartmentalized than previously thought
5 Articles
5 Articles
How cells respond to stress is more nuanced than previously believed
The body's cells respond to stress -- toxins, mutations, starvation or other assaults -- by pausing normal functions to focus on conserving energy, repairing damaged components and boosting defenses. If the stress is manageable, cells resume normal activity; if not, they self-destruct. Scientists have believed for decades this response happens as a linear chain of events: sensors in the cell 'sound an alarm' and modify a key protein, which then …
Cell's stress response is more nuanced and compartmentalized than previously thought
The body's cells respond to stress-toxins, mutations, starvation or other assaults-by pausing normal functions to focus on conserving energy, repairing damaged components and boosting defenses.
Plasticity of the mammalian integrated stress response
An increased level of phosphorylation of eukaryotic translation initiation factor 2 subunit-α (eIF2α, encoded by EIF2S1; eIF2α-p) coupled with decreased guanine nucleotide exchange activity of eIF2B is a hallmark of the ‘canonical’ integrated stress response (c-ISR)1. It is unclear whether impaired eIF2B activity in human diseases including leukodystrophies2, which occurs in the absence of eIF2α-p induction, is synonymous with the c-ISR. Here we…
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