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Alzheimer's Gene Therapy Could Help Protect the Brain From Damage and Preserve Cognitive Function

  • In 2025, scientists at the University of California, San Diego created a gene therapy that safeguards neurons and helps maintain memory in mice exhibiting symptoms of Alzheimer's disease.
  • This therapy emerged due to Alzheimer's involving harmful protein buildups leading to cognitive decline and the need for treatments beyond managing symptoms.
  • The treatment restored gene expression in affected mice to patterns resembling healthy ones and improved hippocampal-dependent memory usually impaired in Alzheimer's patients.
  • Lead researcher Brian Head said the therapy offers a promising way to mitigate cognitive decline, and the study was published on June 5, 2025.
  • These findings suggest the gene therapy could advance future Alzheimer's treatments pending further research and human trials.
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WCSH broke the news in Portland, United States on Tuesday, June 3, 2025.
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