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Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice

Summary by Nature
Cerebellar ataxia is the primary manifestation of cerebellar degenerative diseases, and mitochondrial dysfunction in Purkinje cells (PCs) plays a critical role in disease progression. In this study, we investigated the feasibility of mitochondria transplantation as a potential therapeutic approach to rescue cerebellar neurodegeneration and elucidate the associated mechanisms. We constructed a conditional Drp1 knockout model in PCs (PCKO mice), c…

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Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice

Cerebellar ataxia is the primary manifestation of cerebellar degenerative diseases, and mitochondrial dysfunction in Purkinje cells (PCs) plays a critical role in disease progression. In this study, we investigated the feasibility of mitochondria transplantation as a potential therapeutic approach to rescue cerebellar neurodegeneration and elucidate the associated mechanisms. We constructed a conditional Drp1 knockout model in PCs (PCKO mice), c…

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PatchMD Launches Innovative Mito Cocktail Patch to Support Mitochondrial Health in Individuals with Autism Spectrum Disorder (ASD)

Las Vegas, NV — PatchMD, a leader in innovative nutrient delivery systems, proudly announces the launch of its new Mito Cocktail Patch, designed to support mitochondrial function for individuals with Autism Spectrum Disorder (ASD). Available starting April 1st, this groundbreaking patch offers a convenient, effective solution to deliver essential nutrients that play a vital role in mitochondrial health. Addressing the Link Between Mitochondrial …

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thenewsfront.com broke the news in on Monday, March 24, 2025.
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