US Edition'Oslo Patient' Likely Cured of HIV After Brother's Stem Cell Transplant
Researchers said the donor cells fully replaced the patient’s immune system, and tests found no functioning HIV in blood, bone marrow or gut.
- On Monday, doctors announced that a 63-year-old Norwegian man known as the 'Oslo patient' has achieved long-term HIV remission five years after receiving a stem cell transplant from his brother.
- The patient's brother carried a rare CCR5-delta-32 genetic mutation that removes the HIV receptor on white blood cells, effectively replacing the recipient's immune system with donor cells carrying the protective gene.
- Tests confirmed no functioning HIV DNA in the patient's gut, bone marrow, and blood; he discontinued antiretroviral therapy two years post-transplant, study co-author Marius Troseid of Oslo University Hospital said.
- The Oslo patient is 'having a great time' and feels like he is 'winning the lottery twice,' lead study author Anders Eivind Myhre said, reflecting his robust recovery and renewed energy.
- While this case is significant, stem cell transplants remain a last-resort treatment for cancer due to severe risks including infection or death, and are not feasible for most people with HIV, oncologist Jingmei Hsu of NYU Langone Health said.
54 Articles
54 Articles
Long-term HIV-1 remission achieved through allogeneic haematopoietic stem cell transplant from a CCR5Δ32/Δ32 sibling donor - Nature Microbiology
Only few cases of human immunodeficiency virus (HIV) remission have been reported after allogeneic haematopoietic stem cell transplantation (HSCT), mostly involving stem cell donors with the homozygous CCR5Δ32 (CCR5Δ32/Δ32) mutation, which confers resistance to CCR5-tropic HIV-1. Here we report the case of a 63-year-old man in off-treatment HIV remission, 5 years after HSCT with a CCR5Δ32/Δ32 sibling donor for myelodysplastic syndrome. In-depth …
A 63-year-old Norwegian, HIV-positive since 2006, has been in remission of HIV since 2022, after a bone marrow transplant received from his own brother in 2020 — a lucky donor carrying a genetic mutation...
Man Achieves Five-Year HIV Remission Thanks to Brother's Cells
Illustration of HIV structure (Image: Stock image via Getty Images) A 64-year-old man in Oslo has “likely been cured” after being in HIV remission for five years after receiving a stem-cell transplant from his brother, whose rare CCR5Δ32/Δ32 mutation is linked to resistance to many strains of HIV. However, clinicians involved in the case have stressed this is not a realistic route to a widely available cure. The transplant was carried out to tre…
He was sure he was going to die. Finally, he defeated his blood cancer, and cured HIV. The story of the "Oslo patient" is told in a new study.
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