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Living with Friedreich’s Ataxia: The loneliness of losing control

Summary by neurologylive.com
An expert discusses how omaveloxolone is a nuclear factor erythroid 2-related factor 2 (Nrf2) activator that addresses oxidative stress and mitochondrial dysfunction in Friedreich ataxia. It works by binding to Keap1, which releases Nrf2 to enter the nucleus and upregulate antioxidant genes. Clinical trials showed modest improvements in neurological function, as measured by modified Friedreich Ataxia Rating Scale scores. Adverse effects include …
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neurologylive.comneurologylive.com

Advancing Friedreich Ataxia Treatment With FDA-Approved Therapies

An expert discusses how omaveloxolone is a nuclear factor erythroid 2-related factor 2 (Nrf2) activator that addresses oxidative stress and mitochondrial dysfunction in Friedreich ataxia. It works by binding to Keap1, which releases Nrf2 to enter the nucleus and upregulate antioxidant genes. Clinical trials showed modest improvements in neurological function, as measured by modified Friedreich Ataxia Rating Scale scores. Adverse effects include …

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Healthing.caHealthing.ca

Living with Friedreich’s Ataxia: The loneliness of losing control

·Toronto, Canada
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Healthing.ca broke the news in Toronto, Canada on Tuesday, March 25, 2025.
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