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Biological sex classification with structural MRI data shows increased misclassification in transgender women

Summary by Nature
Transgender individuals (TIs) show brain-structural alterations that differ from their biological sex as well as their perceived gender. To substantiate evidence that the brain structure of TIs differs from male and female, we use a combined multivariate and univariate approach. Gray matter segments resulting from voxel-based morphometry preprocessing of N = 1753 cisgender (CG) healthy participants were used to train (N = 1402) and validate (20%…

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Twitchy broke the news in United States on Wednesday, March 12, 2025.
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