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SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis

Summary by Nature
Solute carrier family 25 member 51 (SLC25A51) was recently identified as the mammalian mitochondrial NAD+ transporter essential for mitochondria functions. However, the role of SLC25A51 in human disease, such as cancer, remains undefined. Here, we report that SLC25A51 is upregulated in multiple cancers, which promotes cancer cells proliferation. Loss of SLC25A51 elevates the mitochondrial proteins acetylation levels due to SIRT3 dysfunctions, le…

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SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis

Solute carrier family 25 member 51 (SLC25A51) was recently identified as the mammalian mitochondrial NAD+ transporter essential for mitochondria functions. However, the role of SLC25A51 in human disease, such as cancer, remains undefined. Here, we report that SLC25A51 is upregulated in multiple cancers, which promotes cancer cells proliferation. Loss of SLC25A51 elevates the mitochondrial proteins acetylation levels due to SIRT3 dysfunctions, le…

·United Kingdom
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Stemwell Science NewsStemwell Science News

Lysyl Hydroxylase 2 Glucosylates Collagen VI to Drive Lung Cancer Progression

Researchers showed that a galactosylhydroxylysyl glucosyltransferase domain on lysyl hydroxylase 2-modified type-VI collagen to promote LUAD growth and metastasis. [Journal of Clinical Investigation] Full ArticleGraphical Abstract

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jci.orgjci.org

JCI Lysyl hydroxylase 2 glucosylates collagen VI to drive lung cancer progression

Lysyl hydroxylase 2 (LH2) is highly expressed in multiple tumor types and accelerates disease progression by hydroxylating lysine residues on fibrillar collagen telopeptides to generate stable collagen cross links in tumor stroma. Here, we show that a galactosylhydroxylysyl glucosyltransferase (GGT) domain on LH2-modified type-VI collagen (Col6) to promote lung adenocarcinoma (LUAD) growth and metastasis. In tumors generated by LUAD cells lackin…

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jci.org broke the news in on Tuesday, April 1, 2025.
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