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Halda Therapeutics Receives FDA Fast Track Designation for HLD-0915 for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Halda Therapeutics announced that the US FDA granted Fast Track designation to HLD-0915, the company’s lead development candidate, for the treatment of patients with mCRPC. [Halda Therapeutics] Press Release See the Story

Toripalimab, Bevacizumab, and Irinotecan in dMMR/MSI Locally Advanced Colorectal Cancer: First-Stage Results from a Phase Ib/II Trial

This was the first stage of the Phase Ib/II trial evaluating the effectiveness and safety of toripalimab, irinotecan, and bevacizumab in patients with rectal cancer refusing up-front surgery or radiation therapy and patients with T4NanyM0 colon cancer with deficiency of mismatch repair or microsatellite instability. [Cell Reports Medicine] Full ArticleGraphical AbstractCancer Read Article

The Nα-Acetyl-L-Lysine/Loxl2/H2O2 Promotes Intestinal Tumor Growth in Drosophila and Cell Proliferation in Human Colorectal Cancer

Scientists showed that Staphylococcus sciuri promotes Drosophila intestinal tumor growth by inducing intestinal stem cell division. [Cell Reports] Full ArticleGraphical Abstract Read Article

UBE2C-Mediated Ubiquitination of ACSL4 Inhibits Ferroptosis and Promotes Gastric Cancer Progression

Data from TCGA and GEO datasets revealed significant upregulation of UBE2C in gastric cancer tissues, with a negative correlation between UBE2C and ACSL4, a key regulator of ferroptosis. [Discover Oncology] Full Article Read Article

Early-Onset Colorectal Cancer As an Emerging Disease of Metabolic Dysregulation

Investigators synthesize evidence on the relationship of obesity and type 2 diabetes mellitus with early-onset CRC, focusing on pathophysiological mechanisms and the mediating roles of diet and lifestyle factors. [Nature Reviews Endocrinology] AbstractCancer Read Article

Gates Foundation Awards $3 Million in Grants to UMass Chan to Study Gut Health in Pregnant Women in low- and Middle-Income Countries

The Gates Foundation is providing funding to two labs in the Program in Microbiome Dynamics at UMass Chan Medical School for research aimed at improving pregnancy outcomes and gut health in women from low- and middle-income countries. [UMass Chan Medical School] Press Release Read Article

Bifidobacterium animalis Suppresses Non-Small Cell Lung Cancer Progression and Modulates Tumor Immunity through Indole-3-Acetic Acid

Researchers identified distinct disparity in the gut microbiota composition between patients with NSCLC and healthy controls, with Bifidobacterium animalis being markedly decreased in NSCLC. [Cell Reports] Full ArticleGraphical Abstract Read Article

Caloric Restriction Enhances the Efficacy of Anti-Androgen Therapy in Prostate Cancer by Inhibiting Androgen Receptor Translation

Scientists investigated the use of dietary interventions, specifically caloric or protein restriction, in combination with anti-androgen therapy as a treatment for prostate cancer. [Cancer Research] Abstract Read Article

Polystyrene Microspheres Could Inhibit the Ferroptosis of Prostate Cancer Cells via USP39/IGF2BP3/MAPK4 Axis

The authors examined the impact of polystyrene particles on prostate cancer proliferation using in vitro experiments. [Journal of Translational Medicine] Full Article Read Article

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Dual Vector Gene Therapy Trial Offers Hope for Tay-Sachs and Sandhoff Diseases

With Deep NIH Cuts, Research Into Health Disparities Falters

Halda Therapeutics Receives FDA Fast Track Designation for HLD-0915 for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Toripalimab, Bevacizumab, and Irinotecan in dMMR/MSI Locally Advanced Colorectal Cancer: First-Stage Results from a Phase Ib/II Trial

The Nα-Acetyl-L-Lysine/Loxl2/H2O2 Promotes Intestinal Tumor Growth in Drosophila and Cell Proliferation in Human Colorectal Cancer

UBE2C-Mediated Ubiquitination of ACSL4 Inhibits Ferroptosis and Promotes Gastric Cancer Progression

Early-Onset Colorectal Cancer As an Emerging Disease of Metabolic Dysregulation

Gates Foundation Awards $3 Million in Grants to UMass Chan to Study Gut Health in Pregnant Women in low- and Middle-Income Countries

Bifidobacterium animalis Suppresses Non-Small Cell Lung Cancer Progression and Modulates Tumor Immunity through Indole-3-Acetic Acid

Caloric Restriction Enhances the Efficacy of Anti-Androgen Therapy in Prostate Cancer by Inhibiting Androgen Receptor Translation

Polystyrene Microspheres Could Inhibit the Ferroptosis of Prostate Cancer Cells via USP39/IGF2BP3/MAPK4 Axis

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Toripalimab, Bevacizumab, and Irinotecan in dMMR/MSI Locally Advanced Colorectal Cancer: First-Stage Results from a Phase Ib/II Trial

The Nα-Acetyl-L-Lysine/Loxl2/H2O2 Promotes Intestinal Tumor Growth in Drosophila and Cell Proliferation in Human Colorectal Cancer

UBE2C-Mediated Ubiquitination of ACSL4 Inhibits Ferroptosis and Promotes Gastric Cancer Progression

Early-Onset Colorectal Cancer As an Emerging Disease of Metabolic Dysregulation

Gates Foundation Awards $3 Million in Grants to UMass Chan to Study Gut Health in Pregnant Women in low- and Middle-Income Countries

Bifidobacterium animalis Suppresses Non-Small Cell Lung Cancer Progression and Modulates Tumor Immunity through Indole-3-Acetic Acid

Caloric Restriction Enhances the Efficacy of Anti-Androgen Therapy in Prostate Cancer by Inhibiting Androgen Receptor Translation

Polystyrene Microspheres Could Inhibit the Ferroptosis of Prostate Cancer Cells via USP39/IGF2BP3/MAPK4 Axis