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News from Stemwell Science News

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Is Stemwell Science News credible or reliable? Our Factuality score answers both of those questions. When it comes to Stemwell Science News, we’ve assigned a Unknown factuality rating. Ratings are assigned by aggregating scores from Ad Fontes Media and Media Bias/Fact Check.

See all of Stemwell Science News news coverage in one place. Discover how Stemwell Science News’s media bias informs their coverage and compare with thousands of other news outlets. Ground News has come across 672 headlines reported on by Stemwell Science News during the past 3 months.

The Ground News media bias check for Stemwell Science News is . Scores are assigned by aggregating bias scores from Ad Fontes Media, Media Bias/Fact Check, and All Sides. Is Stemwell Science News credible or reliable? Our Factuality score answers both of those questions. When it comes to Stemwell Science News, we’ve assigned a Unknown factuality rating. Ratings are assigned by aggregating scores from Ad Fontes Media and Media Bias/Fact Check.

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Top Stemwell Science News News

Bahrain Makes History with First Successful CRISPR-Based Sickle Cell Treatment Outside the US

Business · Manama

Bahrain Makes History with First Successful CRISPR-Based Sickle Cell Treatment Outside the US

Coverage: 4 sources

MANAMA, Kingdom of Bahrain, Feb. 16, 2025 (GLOBE NEWSWIRE) — The Bahrain Oncology Centre (BOC) has made medical history by successfully treating a sickle cell dis…See the Story

Long-term outcomes of GD2-directed CAR-T cell therapy in patients with neuroblastoma

Long-term outcomes of GD2-directed CAR-T cell therapy in patients with neuroblastoma

34% Center coverage: 3 sources

In a phase 1 clinical trial open to accrual from 2004 to 2009, we treated children with neuroblastoma with Epstein–Barr virus (EBV)-specific T lymphocytes and CD3-activated T cells—each expressing chimeric antigen receptors (CARs) targeting GD2 but without an embedded co-stimulatory sequence (first-generation CARs). These CARs incorporated barcoded sequences to track each infused population. We previously reported outcomes up to 5 years and now …See the Story

Invasion and Metastasis in Cancer: Molecular Insights and Therapeutic Targets

Germany · Germany

Invasion and Metastasis in Cancer: Molecular Insights and Therapeutic Targets

The authors examine the sequential processes of tumor metastasis, elucidate the underlying mechanisms driving organ-tropic metastasis, and systematically analyze therapeutic strategies for metastatic tumors, including those tailored to specific organ involvement. [Signal Transduction and Targeted Therapy] Full ArticleSee the Story

Doublecortin Restricts Neuronal Branching by Regulating Tubulin Polyglutamylation

Doublecortin Restricts Neuronal Branching by Regulating Tubulin Polyglutamylation

Researchers used CRISPR/Cas9 to knock-out the Doublecortin gene in iPSCs and differentiated the cells into cortical neurons. DCX-KO neurons showed reduced velocities of nuclear movements and an increased number of neurites early in neuronal development. [Nature Communications] Full ArticleSee the Story

Pluristyx Enables Safer, Universal Cell Therapy Solutions with Newly Issued US Patent for iACT Stealth™ Technology

United States · United States

Pluristyx Enables Safer, Universal Cell Therapy Solutions with Newly Issued US Patent for iACT Stealth™ Technology

Pluristyx announced the issuance of the induced Allogeneic Cell Tolerance (iACT Stealth) US Patent No. 12,178,835. This patent marks a significant milestone in Pluristyx’s mission to bring advanced cell therapy solutions to the global market. [Pluristyx] Press ReleaseSee the Story

CDK6 Kinase Inhibition Unmasks Metabolic Dependencies in BCR::ABL1+ Leukemia

CDK6 Kinase Inhibition Unmasks Metabolic Dependencies in BCR::ABL1+ Leukemia

Investigators explored the role of CDK6 in the regulation of cellular metabolism in BCR::ABL1+ leukemic cells. Cells lacking kinase active CDK6 displayed altered mitochondria morphology with a defective electron transport chain. [Cell Death & Disease] Full ArticleSee the Story

Nuclear Localization of BRCA1-Associated Protein 1 Is Important in Suppressing Hepatocellular Carcinoma Metastasis via CTCF and NRF1/OGT Axis

Nuclear Localization of BRCA1-Associated Protein 1 Is Important in Suppressing Hepatocellular Carcinoma Metastasis via CTCF and NRF1/OGT Axis

Scientists observed that, while BRCA1-associated protein 1 (BAP1) protein was found mainly in the cytoplasm and less in the nuclei of HCC cell lines, BAP1 expression was predominantly nuclear in HepG2 cells, by cell fractionation and immunofluorescence analyses. [Cell Death & Disease] Full ArticleSee the Story

Multiomic Profiling of T Cell Lymphoma after Therapy with Anti-BCMA CAR T Cells and GPRC5D-Directed Bispecific Antibody

Multiomic Profiling of T Cell Lymphoma after Therapy with Anti-BCMA CAR T Cells and GPRC5D-Directed Bispecific Antibody

Scientists reported a 63-year-old male who received ciltacabtagene autoleucel chimeric antigen receptor (CAR) T cells and the GPRC5D × CD3 bispecific talquetamab for early relapse of his multiple myeloma. [Nature Medicine] AbstractSee the Story

Distinct Leukemogenic Mechanism of Acute Promyelocytic Leukemia Based on Genomic Structure of PML::RARα

Distinct Leukemogenic Mechanism of Acute Promyelocytic Leukemia Based on Genomic Structure of PML::RARα

Investigators showed that leukemic stem cells of the short-type isoform acute promyelocytic leukemia (APL), a subtype of APL defined by different breakpoints of the PML gene, concentrated in the CD34+CD38− fraction and expressed T cell immunoglobulin mucin-3 (TIM-3). [Leukemia] Full ArticleSee the Story

Mechano-Oncogenic Cytoskeletal Remodeling Drives Leukemic Transformation with Mitochondrial Vesicle-Mediated STING Activation

Mechano-Oncogenic Cytoskeletal Remodeling Drives Leukemic Transformation with Mitochondrial Vesicle-Mediated STING Activation

Scientists identified a cytoskeleton-mitochondria remodeling mechanism underlying leukemic transformation by the core-binding factor subunit beta and smooth muscle myosin heavy-chain fusion. [Cell Stem Cell] Full ArticleGraphical AbstractSee the Story

Highly Efficient In Vivo Hematopoietic Stem Cell Transduction Using an Optimized Self-Complementary Adeno-Associated Virus

Highly Efficient In Vivo Hematopoietic Stem Cell Transduction Using an Optimized Self-Complementary Adeno-Associated Virus

Investigators used adeno-associated virus serotype 6 (AAV6) vectors and Cre recombination to systematically optimize the parameters for effective in vivo HSC transduction. They establishing an protocol that achieved functional recombination in over two-thirds of immunophenotypic HSCs. [Molecular Therapy-Methods & Clinical Development] AbstractFull ArticleGraphical AbstractSee the Story

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