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Top Stemwell Science News News

TYBR Health Announces FDA 510(k) Clearance for B3 GEL™ System, a Flowable Bio-Gel to Protect Healing Tissue and Preserve Function
United States · United States

TYBR Health Announces FDA 510(k) Clearance for B3 GEL™ System, a Flowable Bio-Gel to Protect Healing Tissue and Preserve Function

83% Center coverage: 6 sources
/PRNewswire/ -- TYBR Health, a medical device and regenerative medicine company, today announced U.S. Food and Drug Administration (FDA) 510(k) clearance for...See the Story
A Meta-Analysis of Genetic Effects Associated with Neurodevelopmental Disorders and Co-Occurring Conditions

A Meta-Analysis of Genetic Effects Associated with Neurodevelopmental Disorders and Co-Occurring Conditions

100% Center coverage: 2 sources
A systematic understanding of the aetiology of neurodevelopmental disorders (NDDs) and their co-occurrence with other conditions during childhood and adolescence remains incomplete. In the current meta-analysis, we synthesized the literature on (1) the contribution of genetic and environmental factors to NDDs, (2) the genetic and environmental overlap between different NDDs, and (3) the co-occurrence between NDDs and disruptive, impulse control …See the Story
Immunopathogenic Mechanisms and Immunoregulatory Therapies in MASLD
Diabetes

Immunopathogenic Mechanisms and Immunoregulatory Therapies in MASLD

Scientists provide an in-depth discussion of current data related to the immunological mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) and summarize the effects of current and experimental therapies on immunoregulation in MASLD. [Cellular & Molecular Immunology] Full ArticleSee the Story

Patients for Patient Safety in the Context of Rare Diseases

Background: The active involvement of patients and their families in patient safety is essential in healthcare systems. Citizen Science can be useful for this purpose, especially for rare diseases, by gathering data and contributions from patients to design safer environments....See the Story

EGFR-TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Two drug-tolerant persister lung cancer cells with different proliferative capacities were established and identified dipeptidyl peptidase 4 (DPP4) as a potential therapeutic target. [Advanced Science] Full ArticleMedicalSee the Story

Engineering CRISPR System-Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy

The engineered E. coli BL21-derived outer membrane vesicles enable the packaging of multiple genes, resulting in a 7-fold increase in DNA enrichment efficiency and gene silencing in vitro. [Advanced Materials] Full ArticleRead Article

Obtusifolin Mitigates Acute Lung Injury and Improves Cardio-Pulmonary Functions in Acute Lung Injury Model by Modulating Oxidative Stress and NF-κB Signaling.

Scientists investigated the therapeutic effects of obtusifolin against lipopolysaccharide-induced lung and cardiac inflammation/injury using both in vitro and in vivo models. [Naunyn-Schmiedebergs Archives of Pharmacology] AbstractGraphical AbstractRead Article

Unraveling the SOX11-IGF2 Signaling Axis in Early Lung Development: Implications for Lung Disease

Researchers delved into the role of SOX11 in early lung development using a Sox11 knockout mouse model. [Communications Biology] Full ArticleRead Article

O-GlcNAcylation with Ubiquitination Stabilizes METTL3 to Promoting HMGB1 Degradation to Inhibit Ferroptosis and Enhance Gemcitabine Resistance in Pancreatic Cancer

By means of functional gain and loss experiments, the relationship between METTL3 and gemcitabine resistance as well as ferroptosis was explored. [Molecular Medicine] Full ArticleRead Article

Emerin Is an Effector of Oncogenic KRAS-Driven Nuclear Dynamics in Pancreatic Cancer.

Using a model of PDAC, the major histological subtypes of pancreatic cancer, researchers found oncogenic mutant KRAS reduces nuclear size. Transcriptomic and protein expression analysis of mutant KRAS-expressing PDAC cells revealed differential levels of several nuclear envelope-associated genes. [JCI Insight] AbstractGraphical AbstractRead Article

CD8 T Cells As Drivers of Blood-Brain Barrier Disruption

Investigators discuss the mechanisms of CD8 T cell-mediated blood-brain barrier (BBB) disruption, including the roles of antigen presentation through MHC class I molecules, which emerge as an important determining feature of BBB disruption and immune cell infiltration into the brain. [Trends In Neurosciences] AbstractRead Article

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