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Top Stemwell Science News News

FDA · United States

Sarepta says it won't comply with FDA request to stop shipping gene therapy Elevidys

46% Center coverage: 45 sources

See the Story

Alzheimer's Disease

Standardized Brain Cell Atlas to Accelerate Parkinson's and Alzheimer's Research

44% Left coverage: 9 sources

Researchers now have a powerful new way to understand the types of brain cells that are affected in neurodegenerative diseases and to uncover connections between conditions such as Parkinson's, Alzheimer's, and other forms of dementia.See the Story

Alzheimer's Disease

AI-Powered Microscope Predicts and Tracks Protein Aggregation Linked to Brain Diseases

100% Center coverage: 3 sources

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's. But to the human eye, proteins that are destined to form harmful aggregates don't look any different than normal proteins.See the Story

Semaglutide and Tirzepatide Lead the Way in Comprehensive Diabetes and Obesity Management

Pharmacists are pivotal in optimizing GLP-1 receptor agonist therapy.See the Story

Tumor-Instructed Glutamine Synthesis in Cancer-Associated Fibroblasts Promotes Pro-Tumor Macrophages

Scientists found that glutamine synthesis by cancer-associated fibroblasts (CAFs) promotes the polarization of pro-tumorigenic tumor-associated macrophages (TAMs) and supports tumor growth by altering TAM composition, highlighting the pivotal role of CAFs in shaping the immunosuppressive tumor microenvironment. [Journal of Experimental Medicine] Full ArticlePress Release Read Article

Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration

In vivo experiments demonstrated that microspheres promote efficient extracellular matrix synthesis and the autonomous release of lubrication factors at the cellular level. [Advanced Science] Full Article Read Article

Mechanical Reinforced and Self-Healing Hydrogels: Bioprinted Biomimetic Methacrylated Collagen Peptide-Xanthan Gum Constructs for Ligament Regeneration

Methacrylated collagen peptide-xanthan gum bioinks with interpenetrating networks were developed for bioprinting stable constructs, followed by stem cell differentiation. [Advanced Healthcare Materials] Full Article Read Article

Tissue-Like Soft Dual-Network Hydrogel Patch With Instant/Tunable Adhesion and Microenvironment Modulation for Infected Wound Healing

Researchers designed a dual-network hydrogel patch based on an orthogonal cross-linking mechanism with instant/tunable adhesion properties and the function of synergistically modulating the microenvironment. [ACS Nano] AbstractGraphical Abstract Read Article

De Novo Fabrication of Dense Collagen Matrices with Patterned Hierarchical Structures for Corneal Stromal Tissue Repair

To illustrate the potential of collagen patterning, a functional corneal stromal substitute was specifically fabricated that mimics the microstructures of collagen in the cornea-sclera and demonstrates its ability to restore histological structure and function in a rabbit model of corneal defect. [Advanced Materials] Abstract Read Article

Interfacial Silicification Efficiently Drives Osteogenic Differentiation of Mesenchymal Stem Cells without Any Exogenous Osteoinductive Factor

Investigators introduced interfacial silicification, which efficiently induces MSC osteogenic differentiation without the need for exogenous osteoinductive factors such as bone morphogenetic proteins-2 (BMP-2) and dexamethasone. [ACS Nano] AbstractGraphical Abstract Read Article

Subversion of mRNA Degradation Pathways by EWSR1::FLI1 Represents a Therapeutic Vulnerability in Ewing Sarcoma

Scientists reported that independently to its canonical roles in transcription, EWSR1::FLI1 also functions as an mRNA decay factor, reshaping mRNA stability in Ewing sarcoma. [Nature Communications] Full Article Read Article

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Top Stemwell Science News News

Sarepta says it won't comply with FDA request to stop shipping gene therapy Elevidys

Standardized Brain Cell Atlas to Accelerate Parkinson's and Alzheimer's Research

AI-Powered Microscope Predicts and Tracks Protein Aggregation Linked to Brain Diseases

Semaglutide and Tirzepatide Lead the Way in Comprehensive Diabetes and Obesity Management

Tumor-Instructed Glutamine Synthesis in Cancer-Associated Fibroblasts Promotes Pro-Tumor Macrophages

Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration

Mechanical Reinforced and Self-Healing Hydrogels: Bioprinted Biomimetic Methacrylated Collagen Peptide-Xanthan Gum Constructs for Ligament Regeneration

Tissue-Like Soft Dual-Network Hydrogel Patch With Instant/Tunable Adhesion and Microenvironment Modulation for Infected Wound Healing

De Novo Fabrication of Dense Collagen Matrices with Patterned Hierarchical Structures for Corneal Stromal Tissue Repair

Interfacial Silicification Efficiently Drives Osteogenic Differentiation of Mesenchymal Stem Cells without Any Exogenous Osteoinductive Factor

Subversion of mRNA Degradation Pathways by EWSR1::FLI1 Represents a Therapeutic Vulnerability in Ewing Sarcoma

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Semaglutide and Tirzepatide Lead the Way in Comprehensive Diabetes and Obesity Management

Tumor-Instructed Glutamine Synthesis in Cancer-Associated Fibroblasts Promotes Pro-Tumor Macrophages

Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration

Mechanical Reinforced and Self-Healing Hydrogels: Bioprinted Biomimetic Methacrylated Collagen Peptide-Xanthan Gum Constructs for Ligament Regeneration

Tissue-Like Soft Dual-Network Hydrogel Patch With Instant/Tunable Adhesion and Microenvironment Modulation for Infected Wound Healing

De Novo Fabrication of Dense Collagen Matrices with Patterned Hierarchical Structures for Corneal Stromal Tissue Repair

Interfacial Silicification Efficiently Drives Osteogenic Differentiation of Mesenchymal Stem Cells without Any Exogenous Osteoinductive Factor

Subversion of mRNA Degradation Pathways by EWSR1::FLI1 Represents a Therapeutic Vulnerability in Ewing Sarcoma