US EditionJCI Cxcr3 promotes protection from colorectal cancer liver metastasis by driving NK cell infiltration and plasticity
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JCI Cxcr3 promotes protection from colorectal cancer liver metastasis by driving NK cell infiltration and plasticity
The antimetastatic activity of NK cells is well established in several cancer types, but the mechanisms underlying NK cell metastasis infiltration and acquisition of antitumor characteristics remain unclear. Herein, we investigated the cellular and molecular factors required to facilitate the generation of an ILC1-like CD49a+ NK cell population within the liver metastasis (LM) environment of colorectal cancer (CRC). We show that CD49a+ NK cells …
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