LACTB-Induced ERBB3 Degradation Inhibits Lipid Synthesis and Suppresses Glioma Growth

Unusual case of glioma tumor highlights need for molecular testing...

A young girl with an unusual form of low-grade glioma, a type of brain tumor, responded well to standard chemotherapy, emphasizing the value of combining imaging, genetic, and tissue-based testing to guide treatment decisions, a case study shows. In the girl’s case, initial imaging and genetic analysis made a diagnosis challenging. The tumor lacked common mutations typical in pediatric low-grade gliomas — specifically, alterations in the MAP kin…

LACTB-Induced ERBB3 Degradation Inhibits Lipid Synthesis and Suppresses Glioma Growth

Abnormal lipid metabolism is a hallmark of cancer and represents a potential target for anti-cancer strategies. β-lactamase-like protein (LACTB) is a novel tumor suppressor; however, its biological functions and underlying mechanisms in glioma remain poorly understood. In this study, we demons...

Iopofosine I 131 Shows Preliminary Survival Benefit in Pediatric R/R Glioma

The safety profile of iopofosine I 131 in the phase 1b CLOVER-2 trial appears consistent with prior reports of the agent.