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Semaglutide and Tirzepatide off FDA shortage list: What does this mean for weight loss drug access?

  • The FDA approved Wegovy and Zepbound for weight loss, leading to increased discussion about GLP-1 drugs like semaglutide and tirzepatide, originally developed for diabetes management, and now widely debated in medicine and culture.
  • Fueled by social media, off-label use of GLP-1 drugs has surged, with a Storyful Intelligence analysis of 29.9k mentions between February 1, 2024, and March 24, 2025, revealing discussions around conditions like PCOS and addiction.
  • Some celebrities like Sharon Osbourne, who shed 42 pounds, and Whoopi Goldberg have openly discussed using weight loss injections like Ozempic and Mounjaro, while others like Gemma Collins claim these drugs have transformed their lives.
  • Common side effects of GLP-1 drugs include nausea, especially when starting the medication, and more serious risks such as pancreatitis, while long-term effects remain unknown, and the new term 'Ozempic neck' refers to skin changes after using fat jabs.
  • A clinical trial, STRIDE, showed that semaglutide, marketed as Ozempic and Wegovy, improved walking distance and quality of life for diabetes patients with peripheral artery disease, independent of weight loss, leading to calls for Health Canada and global guidelines to incorporate it into practice.
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SELF broke the news in on Wednesday, March 26, 2025.
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