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How Do Cryo-Milling and Lyophilization Affect the Properties of Solid Dispersions with Etodolac?
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How Do Cryo-Milling and Lyophilization Affect the Properties of Solid Dispersions with Etodolac?
Abstract Background: Solid dispersions (SDs) of etodolac (ETD), a poorly water-soluble drug model, were developed to enhance its solubility and dissolution rate by employing various preparation methods and hydrophilic or amphiphilic polymers. Methods: Polyvinylpyrrolidone-poly(vinyl acetate) copolymers (PVP/VA), hydroxypropyl methylcellulose (HPMC) and poloxamer were used as carriers, while cryo-milling and lyophilization were utilized as routin…
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