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Top Pharma Excipients News

Marijuana · New York

Tilray Medical Publishes Pioneering Research on the Pharmacokinetics of THC and CBD Formulations

Coverage: 5 sources

New Study Provides Insight into the Bioavailability of Medical Cannabis Formulations for Therapeutic Treatment...See the Story

Vaccines · Ludwigshafen

The impact of lipid compositions on siRNA and mRNA lipid nanoparticle performance for pulmonary delivery - Pharma Excipients

Abstract Lipid nanoparticles (LNPs) are of significant interest as delivery systems for various RNA therapeutics, not least due to their outstanding success in applications including the COVID-19 vaccines and the siRNA therapeutic Onpattro®. As LNPs consist of different lipids, the lipid composition determines key properties of these particles. This study examines how lipid composition, especially helper and PEG-lipids, and RNA cargo (siRNA and …Read Article

Oxford, England · Oxford

Controlled release of amitriptyline via the transdermal route using SmartReservoirs and hydrogel-forming microneedles - Pharma Excipients

Abstract SmartReservoirs (SRs) are novel drug reservoirs made from a cellulose-based matrix for hydrogel-forming microneedles (HF-MNs). SRs can incorporate drug molecules within a cellulose-based matrix in amorphous form. This significantly improves the solubility of poorly soluble drugs, which enhances drug delivery by allowing for rapid dissolution and absorption once the dosage form is administered. In contrast to improving the solubility of …Read Article

Why Refined Olive Oil IV Offers Superior Quality Compared to Extra Virgin Olive Oil for Pharmaceutical Applications - Pharma Excipients

While extra virgin olive oil is prized in kitchens, it falls short in pharmaceutical use. Refined Olive Oil IV is specially processed to meet strict standards for purity, stability, consistency—making it ideal for high-quality drug formulations. From its controlled composition to pharmacopeial compliance, each quality parameter plays a vital role in ensuring product safety and performance. In the following, you’ll discover what makes Refined Oli…Read Article

Preparation and Characterization of Diclofenac Sodium-Purolite A430MR Complexes for Taste Masking - Pharma Excipients

Abstract The taste of a drug impacts the compliance of patients for oral administration. In this study, the bitter taste of diclofenac sodium (DS) was masked with purolite A430MR through ion exchange. The DS-A430MR complexes (DACs) were prepared at a 1:1 (w/w) drug to resin through a simple aqueous binding process. The key factors affecting release behaviors were identified by optimized experiments. The taste masking effect of the DACs was evalu…Shanghai, China · Shanghai Read Article

Poorly water-soluble APIs in fixed-dose combinations: development, challenges, and opportunities in manufacturing techniques - Pharma Excipients

Abstract The incorporation of poorly soluble active ingredients, which make up the majority of the molecules in development, into fixed-dose combination (FDC) products can be an efficient method to improve the pharmacokinetic properties of these compounds, as well as reduce the side effects and enhance patient compliance by reducing the pill burden. The complexity of formulation development is given by the potential antagonistic interactions pre…Read Article

Rethinking Pharmaceutical Industry with Quality by Design: Application in Research, Development, Manufacturing, and Quality Assurance - Pharma Excipients

Abstract Quality by Design (QbD) is a transformative and systematic approach to developing top-tier pharmaceutical products, ushering in a departure from traditional trial-and-error methods toward a more science-based, risk-oriented, and holistic strategy. Central to QbD implementation is the meticulous development of formulations and manufacturing processes, consistently fulfilling predefined quality objectives. The core objective of QbD remain…Read Article

Assessment of leachables and extractables in “super-swelling” hydrogel-forming microarray patches - Pharma Excipients

Abstract Hydrogel-forming microarray patches (MAPs) offer a minimally invasive platform for transdermal drug delivery, enabling systemic absorption of active pharmaceutical ingredients. Unlike dissolving MAPs, which deposit their entire polymer matrix into the skin, hydrogel-forming MAPs remain intact upon removal, reducing polymer exposure while delivering higher drug doses than dissolving or coated MAPs. Moreover, they have demonstrated excell…Read Article

Safety Evaluation of Long-term Administration of Umbilical Mesenchymal Stem Cell-Derived Extracellular Vesicles

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) hold significant therapeutic promise in regenerative medicine; however, their long-term safety profile remains inadequately characterized for clinical translation. In this study, human umbilical cord MSC-derived EVs (hucMSC-EVs) we...Barcelona · Barcelona See the Story

Shaping tomorrows tablets at Compaction Simulation Forum 2025 in San Francisco - Pharma Excipients

Adrien Pelloux From June 9 to 11, 2025, MEDELPHARM and KORSCH took part in the Compaction Simulation Forum (CSF) in San Francisco. Known for their leadership in compaction simulation, both companies used this year’s event to share innovative research through scientific posters, focusing on real manufacturing challenges and future directions in tablet development. First Poster: The role of temperature on tablet attributes Evolution of critica…San Francisco, California · San Francisco Read Article

Elimination of “lag” and “burst” phases in drug release profiles of melt-extruded, PLGA-based intravitreal implants - Pharma Excipients

Abstract Drug delivery products based on poly(lactic-co-glycolic acid) (PLGA) often have multiphasic drug release profiles with slow “lag phase(s)” and rapid “burst phase(s),” which can limit therapeutic efficacy. The purpose of this study was to develop voriconazole (VCZ)/PLGA intravitreal implants with steady drug release profiles, i.e., without lag and burst phases. This study was performed by manufacturing several implant formulations by mel…Shenzhen · Shenzhen Read Article

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Top Pharma Excipients News

Tilray Medical Publishes Pioneering Research on the Pharmacokinetics of THC and CBD Formulations

The impact of lipid compositions on siRNA and mRNA lipid nanoparticle performance for pulmonary delivery - Pharma Excipients

Controlled release of amitriptyline via the transdermal route using SmartReservoirs and hydrogel-forming microneedles - Pharma Excipients

Why Refined Olive Oil IV Offers Superior Quality Compared to Extra Virgin Olive Oil for Pharmaceutical Applications - Pharma Excipients

Preparation and Characterization of Diclofenac Sodium-Purolite A430MR Complexes for Taste Masking - Pharma Excipients

Poorly water-soluble APIs in fixed-dose combinations: development, challenges, and opportunities in manufacturing techniques - Pharma Excipients

Rethinking Pharmaceutical Industry with Quality by Design: Application in Research, Development, Manufacturing, and Quality Assurance - Pharma Excipients

Assessment of leachables and extractables in “super-swelling” hydrogel-forming microarray patches - Pharma Excipients

Safety Evaluation of Long-term Administration of Umbilical Mesenchymal Stem Cell-Derived Extracellular Vesicles

Shaping tomorrows tablets at Compaction Simulation Forum 2025 in San Francisco - Pharma Excipients

Elimination of “lag” and “burst” phases in drug release profiles of melt-extruded, PLGA-based intravitreal implants - Pharma Excipients

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