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Top Pharma Excipients News

United States · United States

Development and Characterization of α-Lipoic Acid Amorphous Solid Dispersion for Improved Oral Bioavailability and Modulation of Allergic Airway Inflammation - Pharma Excipients

To overcome these limitations we have developed LASD using SOL to improve its oral bioavailability and therapeutic efficacy for modulating OVA-LPS.Read Article

Fairfield, New Jersey · Fairfield

Biosurfactant Stabilized Nanosuspension of KRAS inhibitor - Sotorasib (AMG-510): Systematic optimization using Quality by Design Approach - Pharma Excipients

Abstract This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by Design (QbD) approach to enhance solubility, dissolution, and oral bioavailability. A QbD framework use for identification, optimization and validation of critical process and formulation parameters, significantly influcing key quality attributes of nanosuspension. A stable sotorasib nanocrystal formula…Read Article

Germany · Germany

Anticancer Activity of Phospholipid-Dexibuprofen Conjugates Loaded in Nanostructured Lipid Carriers - Pharma Excipients

Abstract Purpose: In our work, we focused on the development of nanostructured lipid carriers (NLCs) loaded with dexibuprofen (DXI) and their application for cancer therapy by proposing the binding of phospholipids with this non-steroidal anti-inflammatory drug (NSAID) to obtain new delivery systems. Methods: We successfully synthesized seven conjugates with good yields, four of which are new, and have not been previously published in the litera…Read Article

Predicting the tabletability of binary powder mixtures from that of individual components - Pharma Excipients

Abstract Predicting the tabletability, i.e., the relationship between tensile strength and compaction pressure, of powder mixtures based on that of pure materials would streamline tablet formulation development, saving both time and materials. This would be a significant step toward achieving digital tablet formulation design. The recently derived Vreeman-Sun tabletability equation enables the mathematical description of tabletability data using…Ludwigshafen · Ludwigshafen Read Article

Smarter Stabilization for Lipid Nanoparticles: Formulating Biopharmaceuticals with Sucrose - Pharma Excipients

We are glad to present our new webinar in collaboration with our partner Nagase Viita: Smarter Stabilization for Lipid Nanoparticles: Formulating Biopharmaceuticals with Sucrose REGISTRATION Learnings: Toward Sustainable Excellence: Developing High-Quality Saccharides for Pharmaceutical Excipient with Stable Supply Sucrose-Enhanced Stabilization of Lipid Nanoparticles for Advanced Drug Delivery Applications Molecular Dynamics Insights into S…Fukuoka · Fukuoka Read Article

Development, characterization, and in vitro evaluation of poly(ethylene oxide)-block-poly(ε-caprolactone)-α-tocopheryl succinate micelles as a novel nanocarrier for rapamycin delivery - Pharma Excipients

Abstract Rapamycin holds significant therapeutic potential for various diseases; however, its clinical application is limited by several formulation challenges, primarily its extremely low aqueous solubility (2.6 μg/mL). To address this, nanoparticle-based delivery systems have emerged as a promising strategy to enhance solubility and enable sustained drug release. Currently, Fyarro® (Aadi Bioscience, Inc.), an albumin-bound nanoparticle formula…Morris Plains · Morris Plains Read Article

3D-Printed cannabidiol stent for local treatment of urinary tract infections - Pharma Excipients

Abstract Urinary tract infections (UTIs) are highly prevalent among women and those assigned female at birth, and frequently necessitate the administration of systemic antibiotics, which contributes to the antibiotic resistance crisis due to overuse and suboptimal patient adherence. This study introduces an innovative 3D-printed stent designed specifically for the localized treatment of UTIs, aiming at reducing systemic drug exposure and lowerin…UTI · Germany Read Article

MEGGLE’s MicroceLac® Plus - A new benchmark in tabletability by outperforming conventional DC excipients - Pharma Excipients

MicroceLac® Plus The new co-processed Excipient for Direct Compression (DC) What’s new? What’s special? MicroceLac® Plus is an innovative addition to the MEGGLE co-processed excipients line, combining 35% alpha-lactose monohydrate and 65% microcrystalline cellulose (MCC) to enhance tablet formulations. This CPE offers a remarkable set of advantages, most notably its superior tabletability! It achieves tablet hardness that exceeds not only its in…Bavaria · Bavaria Read Article

Combining high throughput ASD screening with the rDCS to streamline development of poorly soluble drugs - Pharma Excipients

Abstract Poor aqueous solubility and slow dissolution rate of active pharmaceutical ingredients (APIs) are often encountered challenges during oral drug development, leading to variable and insufficient bioavailability. To overcome these challenges, a so-called “enabling” formulation strategy is often pursued. Among these, amorphous solid dispersions (ASDs) are established as an effective means of improving drug absorption. However, evaluating t…San Diego · San Diego Read Article

Phospholipid-Based Delivery Systems: Phospholipids as Excipients in Advanced Veterinary Drugs - Pharma Excipients

Abstract Phospholipids are excellent natural excipients for veterinary applications. They are essential components of the membrane of any biological cell. They accommodate membrane proteins, creating membranes with highly selective permeability properties necessary for cell survival. Thanks to this natural versatility, phospholipids are multipurpose excipients for pharmaceutical applications in a wide range of drug products. Their unique physico…Germany · Germany Read Article

The Role of Excipients in Determining Nitrosamine Risks for Drug Products - Pharma Excipients

We are glad to present our new webinar in collaboration with our partner Shin-Etsu: The Role of Excipients in Determining Nitrosamine Risks for Drug Products You will see two interesting presentations: Dr. Mike Tobyn: The role of excipients in determining-Nitrosamines risks for drug products Dr. Shingo Kikuchi : A Rapid Analytical Method for Nitrite Determination in Cellulose based Excipients Your key learnings will be: Understanding the imp…Amsterdam, Netherlands · Amsterdam Read Article

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Top Pharma Excipients News

Development and Characterization of α-Lipoic Acid Amorphous Solid Dispersion for Improved Oral Bioavailability and Modulation of Allergic Airway Inflammation - Pharma Excipients

Biosurfactant Stabilized Nanosuspension of KRAS inhibitor - Sotorasib (AMG-510): Systematic optimization using Quality by Design Approach - Pharma Excipients

Anticancer Activity of Phospholipid-Dexibuprofen Conjugates Loaded in Nanostructured Lipid Carriers - Pharma Excipients

Predicting the tabletability of binary powder mixtures from that of individual components - Pharma Excipients

Smarter Stabilization for Lipid Nanoparticles: Formulating Biopharmaceuticals with Sucrose - Pharma Excipients

Development, characterization, and in vitro evaluation of poly(ethylene oxide)-block-poly(ε-caprolactone)-α-tocopheryl succinate micelles as a novel nanocarrier for rapamycin delivery - Pharma Excipients

3D-Printed cannabidiol stent for local treatment of urinary tract infections - Pharma Excipients

MEGGLE’s MicroceLac® Plus - A new benchmark in tabletability by outperforming conventional DC excipients - Pharma Excipients

Combining high throughput ASD screening with the rDCS to streamline development of poorly soluble drugs - Pharma Excipients

Phospholipid-Based Delivery Systems: Phospholipids as Excipients in Advanced Veterinary Drugs - Pharma Excipients

The Role of Excipients in Determining Nitrosamine Risks for Drug Products - Pharma Excipients

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