SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1

SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1

Ageing-induced skeletal muscle deterioration contributes to sarcopenia and frailty, adversely impacting the quality of life in the elderly. However, the molecular mechanisms behind primate skeletal muscle ageing remain largely unexplored. Here, we show that SIRT5 expression is reduced in aged primate skeletal muscles from both genders. SIRT5 deficiency in human myotubes hastens cellular senescence and intensifies inflammation. Mechanistically, w…

Report on the ageing-related research landscape in the UK - Vivensa Foundation

The Vivensa Foundation has today released an in-depth report examining the landscape of ageing-related research funding in the UK. This analysis sheds light on the gaps, challenges, and opportunities within the field of ageing research, with the aim to provide insights for researchers, policymakers, and funders alike. As the UK’s population continues to age, the implications for healthcare, social services, and society as a whole are becoming in…

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2-Mediated Changes

The authors aimed to understand how aging impacts mitochondrial 3D structure and its regulators in skeletal muscle. They hypothesized that aging led to remodeling of mitochondrial 3D architecture permissive to dysfunction and was ameliorated by exercise. [Aging Cell] Full Article

Grape consumption found to influence muscle gene expression in aging mice

New research links whole grape consumption to improved markers of muscle health and reduced sex-related gene differences.