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Balance between two competing nerve proteins deters symptoms of autism in mice

Summary by Science Daily

In mice, autism symptoms arise when a certain pair of competing nerve proteins falls out of equilibrium, according to a new study.

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Balance between two competing nerve proteins deters symptoms of autism in mice

In mice, autism symptoms arise when a certain pair of competing nerve proteins falls out of equilibrium, according to a new study.

2 days ago·United States

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Neuroscience News

Protein Imbalance Triggers Autism-Like Behavior

A new study reveals that autism-like symptoms in mice emerge when two nerve proteins—MDGA2 and BDNF—fall out of balance. MDGA2 typically keeps BDNF/TrkB signaling in check, but when MDGA2 levels drop, heightened neuronal activity and social impairments occur.

3 days ago

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GEN - Genetic Engineering and Biotechnology News…

Autism Symptoms in Mice Linked To Nerve Proteins Falling Out of Equilibrium

Scientists at Wenzhou Medical University and Xiamen University have shown how autism symptoms in mice arise when a certain pair of competing nerve proteins falls out of equilibrium. The results of the team’s study, reported in PLOS Biology could point to potential therapeutic approaches for autism spectrum disorder (ASD). In their paper, titled “Mdfa2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevan…

3 days ago

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Sky News: The Latest News from the World

Disrupted Protein Balance: The Surprising Key to Autism Symptoms – Sky News: The Latest News from the World

Scientists studying mice have uncovered a delicate protein rivalry in the brain that, when thrown off balance, may cause autism-like behaviors. This discovery opens up a potentially powerful new path for autism treatment by targeting how nerve signals are regulated at the molecular level. Protein Imbalance Tied to Autism Symptoms Autism-like symptoms in mice appear […]

3 days ago

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BIOENGINEER.ORG

Equilibrium of Competing Nerve Proteins Helps Alleviate Autism Symptoms in

In a groundbreaking study published in the esteemed journal PLOS Biology, researchers have shed new light on the intricate biological mechanisms associated with Autism Spectrum Disorder (ASD). The research team, led by Dongdong Zhao from Wenzhou Medical University, has explored the role of competing neuronal proteins in the emergence of autism-like behaviors in mice. This pivotal work, released on April 1, 2025, opens new avenues for understandi…

3 days ago

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Medical Xpress

Balance between two competing nerve proteins deters symptoms of autism in mice, study finds

In mice, autism symptoms arise when a certain pair of competing nerve proteins falls out of equilibrium, according to a study published in the open-access journal PLOS Biology by Dongdong Zhao of Wenzhou Medical University, China, Yun-wu Zhang of Xiamen University, China, and colleagues.

3 days ago

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