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Top GEN - Genetic Engineering and Biotechnology News… News

EPA employees put names to 'declaration of dissent' over agency moves under Trump
EPA · United States

EPA employees put names to 'declaration of dissent' over agency moves under Trump

62% Center coverage: 67 sources
See the Story
Dietary Control of Peripheral Adipose Storage Capacity Through Membrane Lipid Remodelling
Obesity

Dietary Control of Peripheral Adipose Storage Capacity Through Membrane Lipid Remodelling

Coverage: 4 sources
Genetic and dietary cues are known drivers of obesity, yet how they converge at the molecular level is incompletely understood. Here we show that PPARγ supports hypertrophic expansion of adipose tissue via transcriptional control of LPCAT3, an endoplasmic reticulum (ER)-resident O-acyltransferase that selectively enriches diet-derived omega-6 polyunsaturated fatty acids (n-6 PUFAs) in the membrane lipidome. In mice fed a high-fat diet, lowering …See the Story
Corticosteroids May Reduce Effectiveness of Immunotherapy in Lung Cancer
AMD · Los Angeles

Corticosteroids May Reduce Effectiveness of Immunotherapy in Lung Cancer

75% Center coverage: 4 sources
Corticosteroids, a commonly prescribed medication to alleviate cancer-related symptoms for non-small cell lung cancer patients treated with immunotherapy, are the main reason certain immunotherapies may fail in treating the disease, according to new research by Keck Medicine of USC.See the Story

Targeted in Vivo Gene Integration of a Secretion-Enabled GLP-1 Receptor Agonist Reverses Diet-Induced Non-Genetic Obesity and Pre-Diabetes

100% Center coverage: 2 sources
In vivo genome editing offers a long-term therapeutic approach for monogenic diseases by directly modifying genetic sequences. However, its application to non-monogenic, noncommunicable diseases, which are the leading causes of global mortality, remains limited due to the lack of well-defined genetic targets. We developed an in vivo genome-editing approach to introduce a gene encoding the glucagon-like peptide-1 (GLP-1) receptor agonist Exendin-…Diabetes · OsakaSee the Story

Immunosuppression for Immune-Related Adverse Events During Checkpoint Inhibition: an Intricate Balance

100% Center coverage: 1 sources
Immune checkpoint inhibitors (ICIs) have changed perspectives for patients with cancer, but come with severe immune-related adverse events (irAEs). To prevent fatality or chronicity, these irAEs are often promptly treated with high-dose immunosuppressants. Until recently, evidence on the effects of irAE management on ICI efficacy has been sparse. As a result, algorithms for irAE management are mostly expert-opinion based and barely consider poss…Diabetes · Los AngelesSee the Story

Continuous Manufacturing Helps mAb Firms Innovate and Cut Costs

Continuous manufacturing makes monoclonal antibody production faster, cheaper, and greener, say researchers, who predict that industry adoption of the approach will accelerate in response to competitive pressure. Most therapeutic antibodies are made as batches, using discrete processes that run for a defined period. This, in large part, reflects the success of early drugs like Enbrel, Humira, and Avastin, which established fed-batch processes as…United States · United StatesRead Article

Iambic and Revolution Medicines Partner on AI Cancer Drug Discovery

Revolution Medicines, a late-stage clinical oncology company, and Iambic Therapeutics, an AI-driven drug discovery company, have announced a multi-year technology and research collaboration to pursue novel drug candidates using Iambic’s AI models.   Iambic will use Revolution Medicine’s structures and molecular libraries to train a bespoke version of NeuralPLexer, Iambic’s AI model for protein-ligand structure prediction.  Both companies will ha…Artificial Intelligence · MarylandRead Article

End-to-End: Fujifilm Rebrands Life Sciences Companies, Positioning Itself as Drug Development Cycle Leader

“What’s in a name? That which we call a rose by any other name would smell as sweet,” Juliet famously observed in Shakespeare’s Romeo and Juliet. More than 400 years later, Fujifilm’s Life Sciences Group is renaming two of its companies, in a rebranding intended to position parent company Fujifilm as a strategic partner to drug and vaccine developers across the development life cycle. Lars Petersen, Fujifilm Biotechnologies president and CEO Fuj…College Station · College StationRead Article

Axplora Plans to Expand Its Farmabios Site

Axplora reports that it has invested €35 million ($40.2 million) to expand its Farmabios site in Gropello Cairoli, Italy. This follows a previous €45 million ($52.7 million) investment which brings the total to over €80 million ($93.7 million). The addition of 62,000 square meters (667,000 square feet) of new development in 2026 will more than double the total footprint of the site to 108,000 square meters (1,162,500 square feet). According to M…Lombardy, Italy · LombardyRead Article

Myrtelle Launches Manufacturing of First-in-Class Gene Therapy for Canavan Disease in Strategic Alliance with Charles River and Viralgen

Team prepares for commercialization bolstered by START Program and regulatory recognitionDurham, North Carolina · DurhamSee the Story

"In-Region, For Region": Cytiva Builds Out $1.6B in Global Expansion Projects

Cytiva is planning for a busy second half as it completes and builds out a combined $1.6 billion in expansion projects worldwide, across the United States, Europe, and Asia, all to meet growing market demand for its services from developers and manufacturers of advanced therapeutics. Two of Cytiva’s top executives recently offered updates on the expansion projects and other initiatives announced since last summer, while a third highlighted the c…Marlborough, Massachusetts · MarlboroughRead Article

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