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Top GEN - Genetic Engineering and Biotechnology News… News

ObesityGenetic and dietary cues are known drivers of obesity, yet how they converge at the molecular level is incompletely understood. Here we show that PPARγ supports hypertrophic expansion of adipose tissue via transcriptional control of LPCAT3, an endoplasmic reticulum (ER)-resident O-acyltransferase that selectively enriches diet-derived omega-6 polyunsaturated fatty acids (n-6 PUFAs) in the membrane lipidome. In mice fed a high-fat diet, lowering …See the Story
Dietary Control of Peripheral Adipose Storage Capacity Through Membrane Lipid Remodelling
Coverage: 4 sources

AMD · Los AngelesCorticosteroids, a commonly prescribed medication to alleviate cancer-related symptoms for non-small cell lung cancer patients treated with immunotherapy, are the main reason certain immunotherapies may fail in treating the disease, according to new research by Keck Medicine of USC.See the Story
Corticosteroids May Reduce Effectiveness of Immunotherapy in Lung Cancer
75% Center coverage: 4 sources
Targeted in Vivo Gene Integration of a Secretion-Enabled GLP-1 Receptor Agonist Reverses Diet-Induced Non-Genetic Obesity and Pre-Diabetes
100% Center coverage: 2 sources
Immunosuppression for Immune-Related Adverse Events During Checkpoint Inhibition: an Intricate Balance
100% Center coverage: 1 sources