Loss of Colonic Fidelity Enables Multilineage Plasticity and Metastasis

Loss of colonic fidelity enables multilineage plasticity and metastasis

Cancer cell plasticity enables the acquisition of new phenotypic features and is implicated as a major driver of metastatic progression1,2. Metastasis occurs mostly in the absence of additional genetic alterations3–5, which suggests that epigenetic mechanisms are important6. However, they remain poorly defined. Here we identify the chromatin-remodelling enzyme ATRX as a key regulator of colonic lineage fidelity and metastasis in colorectal cance…

Spike-In Enhanced Phosphoproteomics Uncovers Synergistic Signaling Responses to MEK Inhibition in Colon Cancer Cells

Scientists demonstrated that spike-in enhanced detection in DIA effectively identified synergistic signaling responses in colorectal cancer cells, presenting a valuable tool for uncovering new therapeutic targets and strategies in cancer treatment. [Nature Communications] Full Article

ENTR1 Drives Colon Cancer via Glycolysis

In a groundbreaking advance in cancer research, scientists have unveiled the pivotal role of ENTR1, an endosome-associated trafficking regulator, in driving the progression of colon cancer through its regulation of energy metabolism, particularly glycolysis. This discovery not only deepens our understanding of tumor biology but also opens promising avenues for targeted therapeutic interventions aimed at crippling cancer’s metabolic lifelines. Th…