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Increasing physical activity in middle age may protect against Alzheimer's disease

  • As part of a long-term Alzheimer's disease study, Mge Akinci and colleagues monitored neurological changes in 337 participants from Catalonia, Spain.
  • The study investigated how changes in physical activity over four years affected brain structure and amyloid beta accumulation, a toxic protein linked to Alzheimer's.
  • Participants who increased physical activity, even below recommended levels, showed greater cortical thickness, less brain shrinkage, and reduced amyloid beta in memory-related regions.
  • Akinci emphasized that even the smallest levels of physical activity provide health advantages, and the study demonstrated a dose-response relationship, where greater increases in exercise were linked to larger decreases in amyloid beta accumulation.
  • These results underscore the value of encouraging increased exercise during midlife as an important public health approach to potentially lower the global risk of Alzheimer's disease.
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Middle-Age Exercise Protects Brain Against Alzheimer's

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El Mundo broke the news in Madrid, Spain on Wednesday, April 30, 2025.
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