Alzheimer's Brain Edema, Bleeding Rates Reported in Lecanemab Real-World Study
- A retrospective study published May 12, 2025, examined bleeding and brain swelling rates in 234 patients with early Alzheimer's treated with lecanemab at WashU Medicine in St. Louis.
- Researchers led by Drs. Barbara Snider and Suzanne Schindler assessed real-world side effects after lecanemab's FDA approval in 2023, confirming trial findings of mostly manageable adverse events.
- The study found 11 patients with symptoms from amyloid-related imaging abnormalities , mostly asymptomatic cases detected via sensitive brain scans, with no deaths reported and effects resolving in months.
- Dr. Schindler noted that the majority of individuals receiving lecanemab experience good tolerance to the treatment, with only 1.8% of those showing very mild symptoms developing adverse effects.
- These findings support continued lecanemab use with careful brain monitoring and highlight lower risk in very early-stage patients, aiding informed treatment decisions despite occasional serious side effects.
14 Articles
14 Articles

Algernon to Acquire NoBrainer Imaging Centers, Inc. - Plans to Establish Alzheimer’s Diagnostic and Treatment Medical Clinics Featuring New PET Scan Technology
VANCOUVER, British Columbia, May 13, 2025 (GLOBE NEWSWIRE) -- Algernon Pharmaceuticals Inc. (the “Company” or “Algernon”) (CSE: AGN) (FRANKFURT: AGW0) (OTCQB: AGNPF), a Canadian healthcare and clinical stage drug development company, is pleased to announce it has entered into share…
Alzheimer's Brain Edema, Bleeding Rates Reported in Lecanemab Real-World Study
(MedPage Today) -- Treating early Alzheimer's disease patients with lecanemab (Leqembi) was feasible and most patients tolerated the drug well, a retrospective study at one specialty memory clinic showed. Infusion-related reactions occurred in...
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