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Alzheimer's Brain Edema, Bleeding Rates Reported in Lecanemab Real-World Study

  • A retrospective study published May 12, 2025, examined bleeding and brain swelling rates in 234 patients with early Alzheimer's treated with lecanemab at WashU Medicine in St. Louis.
  • Researchers led by Drs. Barbara Snider and Suzanne Schindler assessed real-world side effects after lecanemab's FDA approval in 2023, confirming trial findings of mostly manageable adverse events.
  • The study found 11 patients with symptoms from amyloid-related imaging abnormalities , mostly asymptomatic cases detected via sensitive brain scans, with no deaths reported and effects resolving in months.
  • Dr. Schindler noted that the majority of individuals receiving lecanemab experience good tolerance to the treatment, with only 1.8% of those showing very mild symptoms developing adverse effects.
  • These findings support continued lecanemab use with careful brain monitoring and highlight lower risk in very early-stage patients, aiding informed treatment decisions despite occasional serious side effects.
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mindbodygreen broke the news in on Monday, May 12, 2025.
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