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Multivariable regression models improve accuracy and sensitive grading of antibiotic resistance mutations in Mycobacterium tuberculosis

Summary by Nature
Rapid genotype-based drug susceptibility testing for the Mycobacterium tuberculosis complex (MTBC) relies on a comprehensive knowledgebase of the genetic determinants of resistance. Here we present a catalogue of resistance-associated mutations using a regression-based approach and benchmark it against the 2nd edition of the World Health Organisation (WHO) mutation catalogue. We train multivariate logistic regression models on over 52,000 MTBC i…

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Multivariable regression models improve accuracy and sensitive grading of antibiotic resistance mutations in Mycobacterium tuberculosis

Rapid genotype-based drug susceptibility testing for the Mycobacterium tuberculosis complex (MTBC) relies on a comprehensive knowledgebase of the genetic determinants of resistance. Here we present a catalogue of resistance-associated mutations using a regression-based approach and benchmark it against the 2nd edition of the World Health Organisation (WHO) mutation catalogue. We train multivariate logistic regression models on over 52,000 MTBC i…

·United Kingdom
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AMR InsightsAMR Insights

Comprehensive Study of Antibiotics and Antibiotic Resistance Genes in Wastewater and Impacted Mediterranean Water Environments - AMR Insights

This comprehensive study investigated the presence and seasonal dynamics of antibiotics and antibiotic resistance genes (ARGs) in wastewater and impacted aquatic environments across two Mediterranean regions in Spain (Ebro River/Delta and Xúquer River/Albufera de València). Researchers analyzed samples for antibiotic residues and ARGs, with a particular focus on Escherichia coli, using a suspect screening approach and a novel prioritization meth…

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AMR Insights broke the news in on Monday, March 31, 2025.
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