US EditionWEHI team makes major strides in the fight against Parkinson's disease
- On March 14, 2025, WEHI researchers announced a significant advancement in understanding Parkinson's disease by determining the first-ever structure of human PINK1 bound to mitochondria.
- Parkinson's disease, the fastest-growing neurodegenerative condition globally and the second most common after Alzheimer's, affects over 200,000 people in Australia and currently lacks a cure or treatment to halt its progression.
- The WEHI team's research elucidated the structure and activation of PINK1, revealing its ability to sense mitochondrial damage and tag ubiquitin in a four-step process, with the first two steps being observed for the first time.
- Professor David Komander, the corresponding author and head of WEHI's Ubiquitin Signalling Division, stated, "This is a significant milestone for research into Parkinson's," expressing hope for future treatments.
- This research, published in Science, could pave the way for new drugs to treat Parkinson's disease, a condition that has a $10 billion impact on the Australian economy and healthcare systems annually.
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Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson’s disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation
In Parkinson’s Disease (PD), elevated serum lysophosphatidylcholine (LPC) levels correlate with disease progression. However, the mechanisms by which abnormal LPC elevation contributes to PD-related neurotoxicity remain poorly understood. This study aims to investigate the pathogenic role of LPC in dopaminergic neuronal damage and elucidates its underlying mechanisms. Our results showed LPC induces α-synuclein aggregation, exacerbating cognitive…
·United Kingdom
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The IndependentReposted by 
The Independent (US)
The Independent (US)Undiscovered cause of Parkinson’s found for first time by scientists
Experts make breakthrough that could pave way for new treatments for neurodegenerative disease
·London, United Kingdom
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