Combining high throughput ASD screening with the rDCS to streamline development of poorly soluble drugs - Pharma Excipients

Combining high throughput ASD screening with the rDCS to streamline development of poorly soluble drugs - Pharma Excipients

Abstract Poor aqueous solubility and slow dissolution rate of active pharmaceutical ingredients (APIs) are often encountered challenges during oral drug development, leading to variable and insufficient bioavailability. To overcome these challenges, a so-called “enabling” formulation strategy is often pursued. Among these, amorphous solid dispersions (ASDs) are established as an effective means of improving drug absorption. However, evaluating t…