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Christina Applegate Hospitalized with Kidney Infection

During the Aug. 5, 2025, episode, Christina Applegate recorded from her Los Angeles hospital bed, revealing she has a severe kidney infection leaving her 'screaming' in 'so much pain' and requiring IV antibiotics.
During her trip to Europe, Applegate began feeling discomfort and thought it was appendicitis, going straight to the hospital upon returning to Los Angeles.
An emergency CT at 2 a.m. revealed infection in both kidneys, and hospital personnel conducted the test, prompting her to demand all possible examinations.
The hospital declined to discharge her, with Christina Applegate assuring co-host Jamie-Lynn Sigler 'things are messy, but I’m going to be OK,' Sigler noting it 'could have been so much worse'.
Living with multiple sclerosis, she has been hospitalized more than 30 times since her 2021 diagnosis, with MS slowing organ function and increasing infection risks.

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la Nacion

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Christina Applegate hospitalized with kidney infection

Actress Christina Applegate is in the hospital fighting an agonizingly painful, double kidney infection with intravenous antibiotics, she revealed Tuesday. Read more...

1 day ago·Vancouver, United States

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